Lymnaea stagnalis as model for translational neuroscience research: From pond to bench.
Neurosci Biobehav Rev
; 108: 602-616, 2020 01.
Article
em En
| MEDLINE
| ID: mdl-31786320
The purpose of this review is to illustrate how a reductionistic, but sophisticated, approach based on the use of a simple model system such as the pond snail Lymnaea stagnalis (L. stagnalis), might be useful to address fundamental questions in learning and memory. L. stagnalis, as a model, provides an interesting platform to investigate the dialog between the synapse and the nucleus and vice versa during memory and learning. More importantly, the "molecular actors" of the memory dialogue are well-conserved both across phylogenetic groups and learning paradigms, involving single- or multi-trials, aversion or reward, operant or classical conditioning. At the same time, this model could help to study how, where and when the memory dialog is impaired in stressful conditions and during aging and neurodegeneration in humans and thus offers new insights and targets in order to develop innovative therapies and technology for the treatment of a range of neurological and neurodegenerative disorders.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estresse Psicológico
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Neurociências
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Envelhecimento
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Modelos Animais
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Pesquisa Translacional Biomédica
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Lymnaea
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Memória
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Transtornos da Memória
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Neurosci Biobehav Rev
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Itália