Synthesis of Polysubstituted Trifluoromethylpyridines from Trifluoromethyl-α,ß-ynones.
J Org Chem
; 85(2): 924-933, 2020 Jan 17.
Article
em En
| MEDLINE
| ID: mdl-31833770
ABSTRACT
A novel and efficient method for synthesis of polysubstituted trifluoromethylpyridine derivatives by the Bohlmann-Rahtz heteroannulation reaction is described, which use trifluoromethyl-α,ß-ynones as trifluoromethyl building blocks to react with ß-enamino esters or ß-enamino ketones in the presence of ZnBr2 to form the trifluoromethylpyridine derivatives in good yields. The protocol has the advantages of readily available starting materials, mild reaction conditions, and high atom economy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2020
Tipo de documento:
Article