Histidine phosphorylation and phosphoryl group transfer in bacterial chemotaxis.
Nature
; 336(6195): 139-43, 1988 Nov 10.
Article
em En
| MEDLINE
| ID: mdl-3185734
A cascade of protein phosphorylation, initiated by autophosphorylation of the CheA protein, may be important in the signal transduction pathway of bacterial chemotaxis. A proteolytic fragment of CheA cannot autophosphorylate, but can still transfer phosphate to proteins that generate excitation and adaptation signals. The site of CheA phosphorylation is His 48; mutants altered at this position are non-chemotactic. Similar mechanisms of transient protein phosphorylation and phosphoryl group transfer seem to be involved in processing sensory data and in activating specific gene expression.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosfatos
/
Proteínas de Bactérias
/
Quimiotaxia
/
Histidina
/
Proteínas de Membrana
Idioma:
En
Revista:
Nature
Ano de publicação:
1988
Tipo de documento:
Article