Formaldehyde-activated WEHI-150 induces DNA interstrand crosslinks with unique structural features.

Pumuye, Paul P; Evison, Benny J; Konda, Shyam K; Collins, J Grant; Kelso, Celine; Medan, Jelena; Sleebs, Brad E; Watson, Keith; Phillips, Don R; Cutts, Suzanne M

Pumuye, Paul P; Evison, Benny J; Konda, Shyam K; Collins, J Grant; Kelso, Celine; Medan, Jelena; Sleebs, Brad E; Watson, Keith; Phillips, Don R; Cutts, Suzanne M.

Afiliação

Pumuye PP; La Trobe Institute for Molecular Science, La Trobe University, Victoria 3086, Australia.
Evison BJ; La Trobe Institute for Molecular Science, La Trobe University, Victoria 3086, Australia.
Konda SK; School of Science, University of New South Wales, Canberra 2610, Australia.
Collins JG; School of Science, University of New South Wales, Canberra 2610, Australia.
Kelso C; School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia.
Medan J; La Trobe Institute for Molecular Science, La Trobe University, Victoria 3086, Australia; Walter and Eliza Hall Institute, Parkville, Victoria 3052, Australia.
Sleebs BE; Walter and Eliza Hall Institute, Parkville, Victoria 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3010, Australia.
Watson K; Walter and Eliza Hall Institute, Parkville, Victoria 3052, Australia.
Phillips DR; La Trobe Institute for Molecular Science, La Trobe University, Victoria 3086, Australia.
Cutts SM; La Trobe Institute for Molecular Science, La Trobe University, Victoria 3086, Australia. Electronic address: s.cutts@latrobe.edu.au.

Bioorg Med Chem ; 28(3): 115260, 2020 02 01.

Article em En | MEDLINE | ID: mdl-31870833

Assuntos

DNA/efeitos dos fármacos; Formaldeído/farmacologia; Mitoxantrona/farmacologia; Animais; Bovinos; Relação Dose-Resposta a Droga; Formaldeído/química; Espectrometria de Massas; Mitoxantrona/análogos & derivados; Mitoxantrona/química; Modelos Moleculares; Estrutura Molecular; Relação Estrutura-Atividade

Palavras-chave

Anthracenediones; Cancer chemotherapy; DNA sequence specificity; Drug-DNA adducts; Mitoxantrone analogues

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: DNA / Mitoxantrona / Formaldeído Limite: Animals Idioma: En Revista: Bioorg Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Austrália

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