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Identification of potential crucial genes associated with vasculogenic mimicry in human osteosarcoma based on gene expression profile.
Yao, N; Ren, K; Gu, X J; Wu, S J; Shi, X; Chang, Q; Li, Y G; Gao, Z X; Jin, Q M; Zhang, J; Wang, C; Zhou, J.
Afiliação
  • Yao N; Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.
  • Ren K; Laboratory of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, China.
  • Gu XJ; Department of Orthopedics, Zhongda Hospital, Southeast University, Nanjing, China.
  • Wu SJ; Institute of Biotechnology, School of Environmental and Chemical Engineering, Dalian Jiaotong University, Dalian, China.
  • Shi X; Department of Orthopedics, Jinling Hospital, Nanjing University, Nanjing, China.
  • Chang Q; Department of Orthopedics, Jinling Hospital, Nanjing University, Nanjing, China.
  • Li YG; Department of Orthopedics, Zhongda Hospital, Southeast University, Nanjing, China.
  • Gao ZX; Department of Orthopedics, Zhongda Hospital, Southeast University, Nanjing, China.
  • Jin QM; Department of Orthopedics, Zhongda Hospital, Southeast University, Nanjing, China.
  • Zhang J; Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.
  • Wang C; Laboratory of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, China.
  • Zhou J; Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.
Neoplasma ; 67(2): 286-295, 2020 Mar.
Article em En | MEDLINE | ID: mdl-31884799
ABSTRACT
We previously reported the presence of vasculogenic mimicry (VM) in human osteosarcoma. However, the mechanistic basis of osteosarcoma VM remains unclear. Three hundred eighty-one upregulated differentially expressed genes (DEGs) and 526 downregulated DEGs between human osteosarcoma cell line 143B and HOS cell exposed to Matrigel were screened out by microarray. GO categories such as "cell adhesion", "angiogenesis" were enriched in 143B group. PATHWAY analysis showed enriched TGF-beta, Wnt and VEGF signaling pathway in 143B group. The hub gene ITGA2 in signal-network of DEGs exhibited pro-VM and pro-metastasis effect. Our study provides fundamental data for further studies regarding molecules involved in osteosarcoma VM.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ósseas / Osteossarcoma / Transcriptoma / Neovascularização Patológica Tipo de estudo: Diagnostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Neoplasma Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China
Texto completo
Imprimir
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PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ósseas / Osteossarcoma / Transcriptoma / Neovascularização Patológica Tipo de estudo: Diagnostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Neoplasma Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China