[Successful treatment of myelodysplastic syndrome-associated autoinflammatory lymphedema with azacytidine].
Rinsho Ketsueki
; 60(12): 1672-1675, 2019.
Article
em Ja
| MEDLINE
| ID: mdl-31902820
ABSTRACT
An 84-year-old woman presented pancytopenia. She was diagnosed with myelodysplastic syndromes (MDS) with excess blasts-1, however, she declined treatment with azacitidine (AZA). Ten months later, bilaterally symmetrical, non-pitting edema appeared on the lower legs. A skin biopsy of the lower leg revealed lymphedema. The appearance and location of the lymphedema suggested an immunologic etiology; however, tests for autoimmune diseases yielded negative results. Therefore, a relationship between MDS and lymphedema was, therefore, speculated. Consequently, treatment with AZA was started, which led to marked improvement in both the lymphedema and pancytopenia. Based on the skin tissue pathology and the improvement in MDS after treatment with AZA, MDS-related autoinflammatory lymphedema was diagnosed.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pancitopenia
/
Doenças Autoimunes
/
Síndromes Mielodisplásicas
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Linfedema
Tipo de estudo:
Risk_factors_studies
Limite:
Aged80
/
Female
/
Humans
Idioma:
Ja
Revista:
Rinsho Ketsueki
Ano de publicação:
2019
Tipo de documento:
Article