Design, synthesis, and structure-activity relationship studies of novel triazole agents with strong antifungal activity against Aspergillus fumigatus.

Ding, Zichao; Ni, Tingjunhong; Xie, Fei; Hao, Yumeng; Yu, Shichong; Chai, Xiaoyun; Jin, Yongsheng; Wang, Ting; Jiang, Yuanying; Zhang, Dazhi

Ding, Zichao; Ni, Tingjunhong; Xie, Fei; Hao, Yumeng; Yu, Shichong; Chai, Xiaoyun; Jin, Yongsheng; Wang, Ting; Jiang, Yuanying; Zhang, Dazhi.

Afiliação

Ding Z; Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China.
Ni T; Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Middle Yanchang Road, Shanghai 200072, China.
Xie F; Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China.
Hao Y; Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China.
Yu S; Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China.
Chai X; Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China.
Jin Y; Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China.
Wang T; Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China.
Jiang Y; Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Middle Yanchang Road, Shanghai 200072, China. Electronic address: 13761571578@163.com.
Zhang D; Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China. Electronic address: zdzhang_yjhx@smmu.edu.cn.

Bioorg Med Chem Lett ; 30(4): 126951, 2020 02 15.

Article em En | MEDLINE | ID: mdl-31926784

Assuntos

Antifúngicos/farmacologia; Aspergillus fumigatus/efeitos dos fármacos; Desenho de Fármacos; Triazóis/síntese química; Antifúngicos/síntese química; Antifúngicos/química; Sítios de Ligação; Candida albicans/efeitos dos fármacos; Candida albicans/metabolismo; Domínio Catalítico; Farmacorresistência Fúngica; Fluconazol/farmacologia; Proteínas Fúngicas/química; Proteínas Fúngicas/metabolismo; Testes de Sensibilidade Microbiana; Simulação de Acoplamento Molecular; Esterol 14-Desmetilase/química; Esterol 14-Desmetilase/metabolismo; Relação Estrutura-Atividade; Triazóis/química; Triazóis/farmacologia

Palavras-chave

Antifungal; CYP51; Molecular docking; Synthesis; Triazole

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aspergillus fumigatus / Triazóis / Desenho de Fármacos / Antifúngicos Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google