Characterization of p29, an estrogen-receptor associated tumor marker.
J Steroid Biochem
; 31(5): 745-50, 1988 Nov.
Article
em En
| MEDLINE
| ID: mdl-3199814
ABSTRACT
Monoclonal antibody D5, raised against cytosolic human estrogen receptor (ER) reacts with p29, a receptor-associated cytoplasmic serine phosphoprotein which does not bind steroid, While p29 selectively binds GTP and to a lesser extent ATP, in vitro GTP binding does not result in p29 phosphorylation. Under ER activating conditions, p29 associates with cytosolic ER; GTP, ATP and sodium molybdate block formation of immunoprecipitable p29-ER complexes. Nucleotide binding data suggest a role for p29 in the estrogen response machinery, possibly at the level of phosphate or nucleotide metabolism.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosfoproteínas
/
Receptores de Estrogênio
/
Biomarcadores Tumorais
/
Proteínas de Choque Térmico
Tipo de estudo:
Risk_factors_studies
Limite:
Female
/
Humans
Idioma:
En
Revista:
J Steroid Biochem
Ano de publicação:
1988
Tipo de documento:
Article
País de afiliação:
Reino Unido