Effect of metformin and detorsion treatment on serum anti-Müllerian hormonelevels and ovarian histopathology in a rat ovarian torsion model
Turk J Med Sci
; 50(2): 455-463, 2020 04 09.
Article
em En
| MEDLINE
| ID: mdl-31999406
ABSTRACT
Background/aim:
Adnexal torsion is a common gynaecological emergency, and considered to be a problem mostly in reproductive-age women. To evaluatethe effect of metformin and detorsion treatment on reducing ovarian reserve in an ovarian torsion model. Materials andmethods:
Twenty-four nonpregnant, Wistar Hannover rats were included in the study. Animals were divided into 3 groups the control group, the detorsion only group, and the metformin + detorsion group. The first group received only laparotomy. In the second group, ovaries were fixed to the abdominal wall after performing 360° ovarian torsion, followed by detorsion after a 3-h period of ischemia. The third group underwent the same torsion and detorsion procedures as the second group, and received 50 mg/kg metformin by gavage for 14 days. Ovarian damage scores, follicle counts, and AMH levels were evaluated.Results:
The total damage score was significantly increased in the detorsion only group compared to the metformin+detorsion and control groups. Pre-operative/post-operative AMH decreases were statistically significant in negative direction in the detorsion only group when compared to the metformin+detorsion and control groups (P = 0.001).Conclusion:
Metformin+detorsion treatment may be effective in protecting the ovarian reserve after ovarian torsion.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ovário
/
Hormônio Antimülleriano
/
Torção Ovariana
/
Metformina
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Turk J Med Sci
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Turquia