Reference values for high attenuation areas on chest CT in a healthy, never-smoker, multi-ethnic sample: The MESA study.
Respirology
; 25(8): 855-862, 2020 08.
Article
em En
| MEDLINE
| ID: mdl-32064731
ABSTRACT
BACKGROUND AND OBJECTIVE:
Normative values for HAA-a quantitative, CT-based measure of subclinical ILD-in healthy adults are needed to improve interpretability in clinical and research settings.METHODS:
HAA was measured on full-lung CT in 3110 participants in the MESA study. Clinical prediction models were developed using a healthy never-smoker subset with normal spirometry (n = 696). RMSE on cross-validation was used as the primary criterion for model selection. Parametric and non-parametric methods were considered. z-Scores were calculated for the entire study sample. Associations between z-scores and several ILD features were estimated.RESULTS:
In the healthy never-smoker subset, the mean age was 69 years with a range of 54-93 years. The median HAA was 4.3% with a range of 2.7-17.8%. Linear regression had better predictive performance than other methods. The final model included race, height, weight, age and sex. The standard error of the estimate was 1.62 with a cross-validated RMSE of 1.64 and an adjusted R2 of 0.139. z-Scores were associated with several ILD outcomes in adjusted models, including ILA (OR 1.40 per z-unit; 95% CI 1.30, 1.52), exertional dyspnoea (OR 1.08 per z-unit; 95% CI 1.02, 1.15) and FVC (expected increase per z-unit -2.49; 95% CI -2.95, - 2.03).CONCLUSION:
We present a reference equation and z-scores to define expected values of HAA on full-lung CT to aid HAA interpretation in middle-aged and older adults.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tórax
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Etnicidade
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Tomografia Computadorizada por Raios X
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Nível de Saúde
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Aterosclerose
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Fumantes
Tipo de estudo:
Prognostic_studies
Limite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Respirology
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Estados Unidos