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Development of the clinical candidate PBD-C06, a humanized pGlu3-Aß-specific antibody against Alzheimer's disease with reduced complement activation.
Hettmann, Thore; Gillies, Stephen D; Kleinschmidt, Martin; Piechotta, Anke; Makioka, Koki; Lemere, Cynthia A; Schilling, Stephan; Rahfeld, Jens-Ulrich; Lues, Inge.
Afiliação
  • Hettmann T; Vivoryon Therapeutics AG, Weinbergweg 22, 06120, Halle (Saale), Germany.
  • Gillies SD; Provenance Biopharmaceuticals, 70 Bedford Rd, Carlisle, MA, 01741, USA.
  • Kleinschmidt M; Fraunhofer Institute for Cell Therapy and Immunology, Department Molecular Drug Biochemistry and Therapy, Weinbergweg 22, 06120, Halle (Saale), Germany.
  • Piechotta A; Fraunhofer Institute for Cell Therapy and Immunology, Department Molecular Drug Biochemistry and Therapy, Weinbergweg 22, 06120, Halle (Saale), Germany.
  • Makioka K; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Boston, MA, 02115, USA.
  • Lemere CA; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Boston, MA, 02115, USA.
  • Schilling S; Vivoryon Therapeutics AG, Weinbergweg 22, 06120, Halle (Saale), Germany.
  • Rahfeld JU; Fraunhofer Institute for Cell Therapy and Immunology, Department Molecular Drug Biochemistry and Therapy, Weinbergweg 22, 06120, Halle (Saale), Germany.
  • Lues I; Vivoryon Therapeutics AG, Weinbergweg 22, 06120, Halle (Saale), Germany. jens-ulrich.rahfeld@izi.fraunhofer.de.
Sci Rep ; 10(1): 3294, 2020 02 24.
Article em En | MEDLINE | ID: mdl-32094456
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Pirrolidonocarboxílico / Ativação do Complemento / Doença de Alzheimer / Anticorpos Monoclonais Humanizados / Imunoterapia Limite: Animals / Humans Idioma: En Revista: Sci Rep Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Pirrolidonocarboxílico / Ativação do Complemento / Doença de Alzheimer / Anticorpos Monoclonais Humanizados / Imunoterapia Limite: Animals / Humans Idioma: En Revista: Sci Rep Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Alemanha