High-content imaging and structure-based predictions reveal functional differences between Niemann-Pick C1 variants.

Vanharanta, Lauri; Peränen, Johan; Pfisterer, Simon G; Enkavi, Giray; Vattulainen, Ilpo; Ikonen, Elina

Vanharanta, Lauri; Peränen, Johan; Pfisterer, Simon G; Enkavi, Giray; Vattulainen, Ilpo; Ikonen, Elina.

Afiliação

Vanharanta L; Department of Anatomy and Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Peränen J; Minerva Foundation Institute for Medical Research, Helsinki, Finland.
Pfisterer SG; Department of Anatomy and Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Enkavi G; Minerva Foundation Institute for Medical Research, Helsinki, Finland.
Vattulainen I; Department of Anatomy and Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Ikonen E; Department of Physics, University of Helsinki, Helsinki, Finland.

Traffic ; 21(5): 386-397, 2020 05.

Article em En | MEDLINE | ID: mdl-32144825

Assuntos

Colesterol; Peptídeos e Proteínas de Sinalização Intracelular; Proteínas; Transporte Biológico; Colesterol/metabolismo; Humanos; Peptídeos e Proteínas de Sinalização Intracelular/genética; Lisossomos/metabolismo; Simulação de Dinâmica Molecular; Proteína C1 de Niemann-Pick; Proteínas/metabolismo

Palavras-chave

Niemann-Pick C1; cholesterol transport; gene variants; late endosomes; lipid droplets; lysosomal storage diseases

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas / Colesterol / Peptídeos e Proteínas de Sinalização Intracelular Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Traffic Assunto da revista: FISIOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Finlândia

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google