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Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy.
Rendo, Veronica; Stoimenov, Ivaylo; Mateus, André; Sjöberg, Elin; Svensson, Richard; Gustavsson, Anna-Lena; Johansson, Lars; Ng, Adrian; OʼBrien, Casey; Giannakis, Marios; Artursson, Per; Nygren, Peter; Cheong, Ian; Sjöblom, Tobias.
Afiliação
  • Rendo V; Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, SE-75185, Uppsala, Sweden.
  • Stoimenov I; Dana-Farber Cancer Institute, 450 Brookline Ave, 02115, Boston, MA, USA.
  • Mateus A; Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, SE-75185, Uppsala, Sweden.
  • Sjöberg E; Uppsala Drug Optimization and Pharmaceutical Profiling Facility (UDOPP), SciLifeLab Chemical Biology Consortium Sweden (CBCS), Department of Pharmacy, Uppsala University, 75123, Uppsala, Sweden.
  • Svensson R; Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, SE-75185, Uppsala, Sweden.
  • Gustavsson AL; Uppsala Drug Optimization and Pharmaceutical Profiling Facility (UDOPP), SciLifeLab Chemical Biology Consortium Sweden (CBCS), Department of Pharmacy, Uppsala University, 75123, Uppsala, Sweden.
  • Johansson L; SciLifeLab Drug Discovery and Development Platform, ADME of Therapeutics facility (UDOPP), Department of Pharmacy, Uppsala University, 75123, Uppsala, Sweden.
  • Ng A; Chemical Biology Consortium Sweden, Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medicinal Biochemistry and Biophysics, Karolinska Institute, 17177, Solna, Sweden.
  • OʼBrien C; Chemical Biology Consortium Sweden, Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medicinal Biochemistry and Biophysics, Karolinska Institute, 17177, Solna, Sweden.
  • Giannakis M; Temasek Life Sciences Laboratory, 1 Research Link, NUS, 117604, Singapore, Singapore.
  • Artursson P; Dana-Farber Cancer Institute, 450 Brookline Ave, 02115, Boston, MA, USA.
  • Nygren P; Dana-Farber Cancer Institute, 450 Brookline Ave, 02115, Boston, MA, USA.
  • Cheong I; Uppsala Drug Optimization and Pharmaceutical Profiling Facility (UDOPP), SciLifeLab Chemical Biology Consortium Sweden (CBCS), Department of Pharmacy, Uppsala University, 75123, Uppsala, Sweden.
  • Sjöblom T; SciLifeLab Drug Discovery and Development Platform, ADME of Therapeutics facility (UDOPP), Department of Pharmacy, Uppsala University, 75123, Uppsala, Sweden.
Nat Commun ; 11(1): 1308, 2020 03 11.
Article em En | MEDLINE | ID: mdl-32161261
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Arilamina N-Acetiltransferase / Neoplasias Colorretais / Perda de Heterozigosidade / Inibidores de Proteínas Quinases / Antineoplásicos Tipo de estudo: Observational_studies / Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Suécia
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Arilamina N-Acetiltransferase / Neoplasias Colorretais / Perda de Heterozigosidade / Inibidores de Proteínas Quinases / Antineoplásicos Tipo de estudo: Observational_studies / Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Suécia