Cytochrome P450 Enzyme-Mediated Bioactivation as an Underlying Mechanism of Columbin-Induced Hepatotoxicity.

Pei, Jiaping; Xiao, Wen; Zhu, Danyan; Ji, Xiaowei; Shi, Liping; Deng, Xiaozhao

Pei, Jiaping; Xiao, Wen; Zhu, Danyan; Ji, Xiaowei; Shi, Liping; Deng, Xiaozhao.

Afiliação

Pei J; Department of Biochemistry and Molecular Biology, School of Basic Medicine, Nanjing Medical University, Nanjing 210029, China.
Xiao W; Huadong Research Institute for Medicine and Biotechnics, No. 293, Zhongshan East Road, Nanjing 210002, China.
Zhu D; School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China.
Ji X; Department of Biochemistry and Molecular Biology, School of Basic Medicine, Nanjing Medical University, Nanjing 210029, China.
Shi L; Department of Biochemistry and Molecular Biology, School of Basic Medicine, Nanjing Medical University, Nanjing 210029, China.
Deng X; Department of Biochemistry and Molecular Biology, School of Basic Medicine, Nanjing Medical University, Nanjing 210029, China.

Chem Res Toxicol ; 33(4): 940-947, 2020 04 20.

Article em En | MEDLINE | ID: mdl-32162908

Assuntos

Sistema Enzimático do Citocromo P-450/metabolismo; Diterpenos/toxicidade; Lactonas/toxicidade; Fígado/efeitos dos fármacos; Administração Oral; Animais; Diterpenos/administração & dosagem; Relação Dose-Resposta a Droga; Humanos; Lactonas/administração & dosagem; Fígado/metabolismo; Masculino; Camundongos; Camundongos Endogâmicos ICR

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistema Enzimático do Citocromo P-450 / Diterpenos / Lactonas / Fígado Limite: Animals / Humans / Male Idioma: En Revista: Chem Res Toxicol Assunto da revista: TOXICOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

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