Adaptation of hydroxymethylbutenyl diphosphate reductase enables volatile isoprenoid production.
Elife
; 92020 03 12.
Article
em En
| MEDLINE
| ID: mdl-32163032
ABSTRACT
Volatile isoprenoids produced by plants are emitted in vast quantities into the atmosphere, with substantial effects on global carbon cycling. Yet, the molecular mechanisms regulating the balance between volatile and non-volatile isoprenoid production remain unknown. Isoprenoids are synthesised via sequential condensation of isopentenyl pyrophosphate (IPP) to dimethylallyl pyrophosphate (DMAPP), with volatile isoprenoids containing fewer isopentenyl subunits. The DMAPPIPP ratio could affect the balance between volatile and non-volatile isoprenoids, but the plastidic DMAPPIPP ratio is generally believed to be similar across different species. Here we demonstrate that the ratio of DMAPPIPP produced by hydroxymethylbutenyl diphosphate reductase (HDR/IspH), the final step of the plastidic isoprenoid production pathway, is not fixed. Instead, this ratio varies greatly across HDRs from phylogenetically distinct plants, correlating with isoprenoid production patterns. Our findings suggest that adaptation of HDR plays a previously unrecognised role in determining in vivo carbon availability for isoprenoid emissions, directly shaping global biosphere-atmosphere interactions.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oxirredutases
/
Plantas
/
Terpenos
/
Compostos Orgânicos Voláteis
Idioma:
En
Revista:
Elife
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Dinamarca