[Two-dimensional parameter of the kinetics of glucose (rho-criterion) in the assessment of the efficacy and prognosis of therapy of diabetes mellitus]. / Dvumernyi parametr kinetiki gliukozy (rho-kriterii) v otsenke éffektivnosti i prognoza lecheniia sakharnogo diabeta.

ABSTRACT

The authors describe the results of i. v. GTT in 10 patients with diabetes mellitus before and after a course of hyperbaric oxygenation, in 5 of them the test was repeated. The results of the test were processed with the help of a new type of model of glucose kinetics based on the production of glucose by the liver and its elimination in the test. A new quantitative criterion (the so-called rho-criterion) of a degree of carbohydrate metabolic derangement was introduced for diabetic patients. Its calculation before and after a course of HBO permitted reliable quantitative assessment of the efficacy of sugar lowering therapy in such patients. The new method permitted the assessment of the production of glucose by the liver and the rate of its elimination in i.v. GTT. The mechanism of HBO-action was unraveled (the suppression of glucose production by the liver). Examples of 2 patients with type II diabetes mellitus have demonstrated the efficacy of the rho-criterion in the prediction of a sugar lowering effect of antidiabetic tablets in serious clinical situations.