Cysteinyl Leukotriene Synthesis via Phospholipase A2 Group IV Mediates Exercise-induced Bronchoconstriction and Airway Remodeling.

Ueno, Hiroshi; Koya, Toshiyuki; Takeuchi, Hiroyuki; Tsukioka, Keisuke; Saito, Akira; Kimura, Yosuke; Hayashi, Masachika; Watanabe, Satoshi; Hasegawa, Takashi; Arakawa, Masaaki; Kikuchi, Toshiaki

Ueno, Hiroshi; Koya, Toshiyuki; Takeuchi, Hiroyuki; Tsukioka, Keisuke; Saito, Akira; Kimura, Yosuke; Hayashi, Masachika; Watanabe, Satoshi; Hasegawa, Takashi; Arakawa, Masaaki; Kikuchi, Toshiaki.

Afiliação

Ueno H; Department of Respiratory Medicine and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Koya T; Department of Respiratory Medicine and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Takeuchi H; Department of Respiratory Medicine and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Tsukioka K; Department of Respiratory Medicine and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Saito A; Department of Respiratory Medicine and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Kimura Y; Department of Respiratory Medicine and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Hayashi M; Department of Respiratory Medicine and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Watanabe S; Department of Respiratory Medicine and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Hasegawa T; Department of General Medicine, Niigata University Medical and Dental Hospital, Niigata, Japan; and.
Arakawa M; Niigata Institute for Health and Sports Medicine, Niigata, Japan.
Kikuchi T; Department of Respiratory Medicine and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Am J Respir Cell Mol Biol ; 63(1): 57-66, 2020 07.

Article em En | MEDLINE | ID: mdl-32182104

Assuntos

Remodelação das Vias Aéreas/fisiologia; Broncoconstrição/fisiologia; Cisteína/metabolismo; Fosfolipases A2 do Grupo II/metabolismo; Leucotrienos/metabolismo; Condicionamento Físico Animal/fisiologia; Acetatos/farmacologia; Remodelação das Vias Aéreas/efeitos dos fármacos; Animais; Asma/tratamento farmacológico; Asma/metabolismo; Hiper-Reatividade Brônquica/tratamento farmacológico; Hiper-Reatividade Brônquica/metabolismo; Broncoconstrição/efeitos dos fármacos; Ciclopropanos; Feminino; Leucotrienos/farmacologia; Pulmão/efeitos dos fármacos; Pulmão/metabolismo; Cloreto de Metacolina/farmacologia; Camundongos; Camundongos Endogâmicos BALB C; Quinolinas/farmacologia; Hipersensibilidade Respiratória/tratamento farmacológico; Hipersensibilidade Respiratória/metabolismo; Sulfetos

Palavras-chave

airway hyperresponsiveness; airway remodeling; cysteinyl-leukotriene; exercise-induced bronchoconstriction; phospholipase A2 group IV

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Condicionamento Físico Animal / Leucotrienos / Broncoconstrição / Cisteína / Fosfolipases A2 do Grupo II / Remodelação das Vias Aéreas Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Revista: Am J Respir Cell Mol Biol Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Japão

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