Noncatalytic Bruton's tyrosine kinase activates PLCÎ³<sub>2</sub> variants mediating ibrutinib resistance in human chronic lymphocytic leukemia cells.

Wist, Martin; Meier, Laura; Gutman, Orit; Haas, Jennifer; Endres, Sascha; Zhou, Yuan; Rösler, Reinhild; Wiese, Sebastian; Stilgenbauer, Stephan; Hobeika, Elias; Henis, Yoav I; Gierschik, Peter; Walliser, Claudia

Noncatalytic Bruton's tyrosine kinase activates PLCÎ³₂ variants mediating ibrutinib resistance in human chronic lymphocytic leukemia cells.

Wist, Martin; Meier, Laura; Gutman, Orit; Haas, Jennifer; Endres, Sascha; Zhou, Yuan; Rösler, Reinhild; Wiese, Sebastian; Stilgenbauer, Stephan; Hobeika, Elias; Henis, Yoav I; Gierschik, Peter; Walliser, Claudia.

Afiliação

Wist M; Institute of Pharmacology and Toxicology, Ulm University Medical Center, 89081 Ulm, Germany.
Meier L; Institute of Pharmacology and Toxicology, Ulm University Medical Center, 89081 Ulm, Germany.
Gutman O; Department of Neurobiology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
Haas J; Institute of Pharmacology and Toxicology, Ulm University Medical Center, 89081 Ulm, Germany.
Endres S; Institute of Pharmacology and Toxicology, Ulm University Medical Center, 89081 Ulm, Germany.
Zhou Y; Institute of Pharmacology and Toxicology, Ulm University Medical Center, 89081 Ulm, Germany.
Rösler R; Core Unit Mass Spectrometry and Proteomics, Medical Faculty, Ulm University Medical Center, 89081 Ulm, Germany.
Wiese S; Core Unit Mass Spectrometry and Proteomics, Medical Faculty, Ulm University Medical Center, 89081 Ulm, Germany.
Stilgenbauer S; Department of Internal Medicine III, Ulm University Medical Center, 89081 Ulm, Germany.
Hobeika E; Institute of Immunology, Ulm University Medical Center, 89081 Ulm, Germany.
Henis YI; Department of Neurobiology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
Gierschik P; Institute of Pharmacology and Toxicology, Ulm University Medical Center, 89081 Ulm, Germany. Electronic address: peter.gierschik@uni-ulm.de.
Walliser C; Institute of Pharmacology and Toxicology, Ulm University Medical Center, 89081 Ulm, Germany. Electronic address: claudia.walliser@uni-ulm.de.

J Biol Chem ; 295(17): 5717-5736, 2020 04 24.

Article em En | MEDLINE | ID: mdl-32184360

Assuntos

Adenina/análogos & derivados; Tirosina Quinase da Agamaglobulinemia/metabolismo; Leucemia Linfocítica Crônica de Células B/tratamento farmacológico; Leucemia Linfocítica Crônica de Células B/genética; Fosfolipase C gama/genética; Piperidinas/farmacologia; Inibidores de Proteínas Quinases/farmacologia; Adenina/farmacologia; Tirosina Quinase da Agamaglobulinemia/antagonistas & inibidores; Animais; Células COS; Linhagem Celular Tumoral; Chlorocebus aethiops; Resistencia a Medicamentos Antineoplásicos; Ativação Enzimática/efeitos dos fármacos; Humanos; Leucemia Linfocítica Crônica de Células B/metabolismo; Fosfolipase C gama/metabolismo; Mutação Puntual/efeitos dos fármacos

Palavras-chave

B-cell receptor (BCR); B-cell signaling; Bruton's tyrosine kinase (BTK); Rac (Rac GTPase); calcium; chronic lymphocytic leukemia (CLL); drug resistance; ibrutinib; inositol phosphate; inositol phospholipid; phosphoinositide; phospholipase C; tyrosineprotein kinase (tyrosine kinase)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperidinas / Adenina / Leucemia Linfocítica Crônica de Células B / Inibidores de Proteínas Quinases / Fosfolipase C gama / Tirosina Quinase da Agamaglobulinemia Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Alemanha

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