Differentiated adipose-derived stem cells promote peripheral nerve regeneration.
Muscle Nerve
; 62(1): 119-127, 2020 07.
Article
em En
| MEDLINE
| ID: mdl-32243602
ABSTRACT
INTRODUCTION:
Many reports have indicated that adipose-derived stem cells (ADSCs) are effective for nerve regeneration. We investigated nerve regeneration by combining a polyglycolic acid collagen (PGA-c) tube, which is approved for clinical use, and Schwann cell-like differentiated ADSCs (dADSCs).METHODS:
Fifteen-millimeter-long gaps in the sciatic nerve of rats were bridged in each group using tubes (group I), with tubes injected with dADSCs (group II), or by resected nerve (group III).RESULTS:
Axonal outgrowth was greater in group II than in group I. Tibialis anterior muscle weight revealed recovery only in group III. Latency in nerve conduction studies was equivalent in group II and III, but action potential was lower in group II. Transplanted dADSCs maintained Schwann cell marker expression. ATF3 expression level in the dorsal root ganglia was equivalent in groups II and III.DISCUSSION:
dADSCs maintained their differentiated state in the tubes and are believed to have contributed to nerve regeneration.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células de Schwann
/
Nervo Isquiático
/
Diferenciação Celular
/
Tecido Adiposo
/
Transplante de Células-Tronco
/
Regeneração Nervosa
Limite:
Animals
Idioma:
En
Revista:
Muscle Nerve
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Japão