Stable, polyvalent aptamer-conjugated near-infrared fluorescent nanocomposite for high-performance cancer cell-targeted imaging and therapy.
J Mater Chem B
; 5(46): 9229-9237, 2017 Dec 14.
Article
em En
| MEDLINE
| ID: mdl-32264606
ABSTRACT
Early diagnosis and targeted therapy are two important ways to improve cancer treatment survival. In this work, via a simple DNA hybridization reaction, DNA-templated fluorescent silver nanoclusters (AgNCs) were successfully assembled around a DNA-modified gold nanoparticle (AuNP) to construct a novel nanocomposite with the functions of cancer cell-specific imaging and targeted therapy. The as-prepared AuNP@(AS1411-AgNCs)n nanocomposite shows strong near-infrared fluorescence emission and improved biostability, and carries a high density of AS1411-the first anticancer aptamer targeting nucleolin protein, which is over-expressed not only on the surface but also in the cytoplasm of cancer cells. The synergy of multivalent AS1411-nucleolin binding promotes accumulation of the nanocomposite towards cancer cells and subsequent internalization in them. This results in highly specific cancer cell-targeted imaging and selective killing in a low AuNP@(AS1411-AgNCs)n concentration range. The prepared nanocomposite also shows great potential as a carrier of doxorubicin to further promote the selective killing of cancer cells.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Screening_studies
Idioma:
En
Revista:
J Mater Chem B
Ano de publicação:
2017
Tipo de documento:
Article