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Intraindividual Neurofilament Dynamics in Serum Mark the Conversion to Sporadic Parkinson's Disease.
Wilke, Carlo; Dos Santos, Marcia Cristina Teixeira; Schulte, Claudia; Deuschle, Christian; Scheller, Dieter; Verbelen, Moira; Brockmann, Kathrin; von Thaler, Anna-Katharina; Sünkel, Ulrike; Roeben, Benjamin; Bujac, Sarah; Metzger, Florian G; Maetzler, Walter; da Costa, Andre Nogueira; Synofzik, Matthis; Berg, Daniela.
Afiliação
  • Wilke C; Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research and Center of Neurology, University of Tübingen, Tübingen, Germany.
  • Dos Santos MCT; German Center for Neurodegenerative Diseases, University of Tübingen, Tübingen, Germany.
  • Schulte C; Experimental Medicine and Diagnostics, Global Exploratory Development, UCB Biopharma, Braine-L'Alleud, Belgium.
  • Deuschle C; Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research and Center of Neurology, University of Tübingen, Tübingen, Germany.
  • Scheller D; German Center for Neurodegenerative Diseases, University of Tübingen, Tübingen, Germany.
  • Verbelen M; Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research and Center of Neurology, University of Tübingen, Tübingen, Germany.
  • Brockmann K; German Center for Neurodegenerative Diseases, University of Tübingen, Tübingen, Germany.
  • von Thaler AK; Consultancy Neuropharm, Neuss, Germany.
  • Sünkel U; Exploratory Statistics, Global Exploratory Development, UCB Pharma, Slough, United Kingdom.
  • Roeben B; Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research and Center of Neurology, University of Tübingen, Tübingen, Germany.
  • Bujac S; German Center for Neurodegenerative Diseases, University of Tübingen, Tübingen, Germany.
  • Metzger FG; Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research and Center of Neurology, University of Tübingen, Tübingen, Germany.
  • Maetzler W; German Center for Neurodegenerative Diseases, University of Tübingen, Tübingen, Germany.
  • da Costa AN; Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research and Center of Neurology, University of Tübingen, Tübingen, Germany.
  • Synofzik M; German Center for Neurodegenerative Diseases, University of Tübingen, Tübingen, Germany.
  • Berg D; Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research and Center of Neurology, University of Tübingen, Tübingen, Germany.
Mov Disord ; 35(7): 1233-1238, 2020 07.
Article em En | MEDLINE | ID: mdl-32338403
BACKGROUND AND OBJECTIVES: With disease-modifying treatment strategies on the horizon, stratification of individual patients at the earliest stages of Parkinson's disease (PD) is key-ideally already at clinical disease onset. Blood levels of neurofilament light chain (NfL) provide an easily accessible fluid biomarker that might allow capturing the conversion from prodromal to manifest PD. METHODS: We assessed longitudinal serum NfL levels in subjects converting from prodromal to manifest sporadic PD (converters), at-risk subjects, and matched controls (72 participants with ≈4 visits), using single-molecule array (Simoa) technique. RESULTS: While NfL levels were not increased at the prodromal stage, subjects converting to the manifest motor stage showed a significant intraindividual acceleration of the age-dependent increase of NfL levels. CONCLUSIONS: The temporal dynamics of intraindividual NfL blood levels might mark the conversion to clinically manifest PD, providing a potential stratification biomarker for individual disease onset in the advent of precision medicine for PD. © 2020 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Filamentos Intermediários Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: Mov Disord Assunto da revista: NEUROLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Alemanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Filamentos Intermediários Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: Mov Disord Assunto da revista: NEUROLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Alemanha