Engineering of l-threonine aldolase for the preparation of 4-(methylsulfonyl)phenylserine, an important intermediate for the synthesis of florfenicol and thiamphenicol.

Liu, Zhicheng; Chen, Xi; Chen, Qijia; Feng, Jinhui; Wang, Min; Wu, Qiaqing; Zhu, Dunming

Liu, Zhicheng; Chen, Xi; Chen, Qijia; Feng, Jinhui; Wang, Min; Wu, Qiaqing; Zhu, Dunming.

Afiliação

Liu Z; Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China; National Engineering Laboratory for Industrial Enzymes and Tianjin Engineering Research Center of Biocatalytic Technology, Tia
Chen X; National Engineering Laboratory for Industrial Enzymes and Tianjin Engineering Research Center of Biocatalytic Technology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, 32 West 7th Avenue, Tianjin Airport Economic Area, Tianjin 300308, China.
Chen Q; National Engineering Laboratory for Industrial Enzymes and Tianjin Engineering Research Center of Biocatalytic Technology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, 32 West 7th Avenue, Tianjin Airport Economic Area, Tianjin 300308, China.
Feng J; National Engineering Laboratory for Industrial Enzymes and Tianjin Engineering Research Center of Biocatalytic Technology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, 32 West 7th Avenue, Tianjin Airport Economic Area, Tianjin 300308, China.
Wang M; Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China.
Wu Q; National Engineering Laboratory for Industrial Enzymes and Tianjin Engineering Research Center of Biocatalytic Technology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, 32 West 7th Avenue, Tianjin Airport Economic Area, Tianjin 300308, China. Electronic address: wu_qq@t
Zhu D; National Engineering Laboratory for Industrial Enzymes and Tianjin Engineering Research Center of Biocatalytic Technology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, 32 West 7th Avenue, Tianjin Airport Economic Area, Tianjin 300308, China. Electronic address: zhu_dm@

Enzyme Microb Technol ; 137: 109551, 2020 Jun.

Article em En | MEDLINE | ID: mdl-32423678

Assuntos

Glicina Hidroximetiltransferase/genética; Engenharia de Proteínas; Serina/análogos & derivados; Tianfenicol/análogos & derivados; Tianfenicol/metabolismo; Catálise; Glicina Hidroximetiltransferase/metabolismo; Mutação; Pseudomonas/enzimologia; Pseudomonas/genética; Serina/biossíntese; Especificidade por Substrato

Palavras-chave

Enzymatic synthesis; Random mutagenesis; Stereoselectivity; Threonine aldolase; ß-Hydroxy-α-amino acid

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Serina / Glicina Hidroximetiltransferase / Tianfenicol / Engenharia de Proteínas Idioma: En Revista: Enzyme Microb Technol Ano de publicação: 2020 Tipo de documento: Article

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