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Evaluation of the efficacy and safety of deferiprone compared with deferasirox in paediatric patients with transfusion-dependent haemoglobinopathies (DEEP-2): a multicentre, randomised, open-label, non-inferiority, phase 3 trial.
Maggio, Aurelio; Kattamis, Antonis; Felisi, Mariagrazia; Reggiardo, Giorgio; El-Beshlawy, Amal; Bejaoui, Mohamed; Sherief, Laila; Christou, Soteroula; Cosmi, Carlo; Della Pasqua, Oscar; Del Vecchio, Giovanni Carlo; Filosa, Aldo; Cuccia, Liana; Hassab, Hoda; Kreka, Manika; Origa, Raffaella; Putti, Maria Caterina; Spino, Michael; Telfer, Paul; Tempesta, Bianca; Vitrano, Angela; Tsang, Yu Chung; Zaka, Ariana; Tricta, Fernando; Bonifazi, Donato; Ceci, Adriana.
Afiliação
  • Maggio A; Department of Hematology and Rare Diseases, V Cervello, Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy. Electronic address: aurelio.maggio@villasofia.it.
  • Kattamis A; First Department of Pediatrics, National and Kapodistriam University of Athens, Athens, Greece.
  • Felisi M; Consorzio per Valutazioni Biologiche e Farmacologiche, Bari-Pavia, Italy.
  • Reggiardo G; Biostatistics and Data Management Unit, Medi Service, Genoa, Italy.
  • El-Beshlawy A; Pediatric Hospital, Cairo University, Cairo, Egypt.
  • Bejaoui M; Pediatrics and Bone Marrow Transplantation Centre, Tunis, Tunisia.
  • Sherief L; Pediatrics Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
  • Christou S; Thalassaemia Center, Hospital Archbishop Makarios III, Nicosia, Cyprus.
  • Cosmi C; Clinica Pediatrica, Azienda Ospedaliero Universitaria (AOU) Sassari, Sassari, Italy.
  • Della Pasqua O; Clinical Pharmacology and Therapeutics Group, University College London, London, UK.
  • Del Vecchio GC; UO Pediatrica B Trambusti, AOU Consorziale Policlinico-Giovanni XXIII, Bari, Italy.
  • Filosa A; UOSD Malattie rare del globulo rosso, AORN A Cardarelli, Napoli, Italy.
  • Cuccia L; UOC Ematologia con Talassemia, Dipartimento di Medicina, AO Civico Di Cristina-Benfratelli, Palermo, Italy.
  • Hassab H; Department of Pediatrics and Clinical Research Center, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
  • Kreka M; Pediatrics Department, University Hospital Center Mother Teresa, Tirana, Albania.
  • Origa R; DH Talassemia, Ospedale Pediatrico Microcitemico A CAO, AO G Brotzu, Cagliari, Italy.
  • Putti MC; Department of Women's and Child's Health (DSDB), University Hospital, Padova, Italy.
  • Spino M; ApoPharma, Toronto, ON, Canada.
  • Telfer P; Centre for Genomics and Child Health, Blizard Institute, Queen Mary University of London, London, UK.
  • Tempesta B; Consorzio per Valutazioni Biologiche e Farmacologiche, Bari-Pavia, Italy.
  • Vitrano A; Department of Hematology and Rare Diseases, V Cervello, Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy.
  • Tsang YC; ApoPharma, Toronto, ON, Canada.
  • Zaka A; Center of Thalassemia, Hospital Ihsan Cabej, Lushnje, Albania.
  • Tricta F; ApoPharma, Toronto, ON, Canada.
  • Bonifazi D; Consorzio per Valutazioni Biologiche e Farmacologiche, Bari-Pavia, Italy.
  • Ceci A; Fondazione per la Ricerca Farmacologica Gianni Benzi Onlus, Valenzano, Italy.
Lancet Haematol ; 7(6): e469-e478, 2020 Jun.
Article em En | MEDLINE | ID: mdl-32470438
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quelantes de Ferro / Transfusão de Eritrócitos / Sobrecarga de Ferro / Deferiprona / Deferasirox / Hemoglobinopatias Tipo de estudo: Clinical_trials / Guideline País/Região como assunto: Africa / Europa Idioma: En Revista: Lancet Haematol Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quelantes de Ferro / Transfusão de Eritrócitos / Sobrecarga de Ferro / Deferiprona / Deferasirox / Hemoglobinopatias Tipo de estudo: Clinical_trials / Guideline País/Região como assunto: Africa / Europa Idioma: En Revista: Lancet Haematol Ano de publicação: 2020 Tipo de documento: Article