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Exome Sequencing Identifies Genes and Gene Sets Contributing to Severe Childhood Obesity, Linking PHIP Variants to Repressed POMC Transcription.
Marenne, Gaëlle; Hendricks, Audrey E; Perdikari, Aliki; Bounds, Rebecca; Payne, Felicity; Keogh, Julia M; Lelliott, Christopher J; Henning, Elana; Pathan, Saad; Ashford, Sofie; Bochukova, Elena G; Mistry, Vanisha; Daly, Allan; Hayward, Caroline; Wareham, Nicholas J; O'Rahilly, Stephen; Langenberg, Claudia; Wheeler, Eleanor; Zeggini, Eleftheria; Farooqi, I Sadaf; Barroso, Inês.
Afiliação
  • Marenne G; Wellcome Sanger Institute, Cambridge, UK; Inserm, Univ Brest, EFS, UMR 1078, GGB, 29200 Brest, France.
  • Hendricks AE; Wellcome Sanger Institute, Cambridge, UK; Mathematical and Statistical Sciences, University of Colorado Denver, Denver, CO, USA.
  • Perdikari A; University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
  • Bounds R; University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
  • Payne F; Wellcome Sanger Institute, Cambridge, UK.
  • Keogh JM; University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
  • Lelliott CJ; Wellcome Sanger Institute, Cambridge, UK.
  • Henning E; University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
  • Pathan S; University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
  • Ashford S; University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
  • Bochukova EG; University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
  • Mistry V; University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
  • Daly A; Wellcome Sanger Institute, Cambridge, UK.
  • Hayward C; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK; Generation Scotland, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
  • Wareham NJ; University of Cambridge MRC Epidemiology Unit, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
  • O'Rahilly S; MRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
  • Langenberg C; University of Cambridge MRC Epidemiology Unit, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
  • Wheeler E; Wellcome Sanger Institute, Cambridge, UK; University of Cambridge MRC Epidemiology Unit, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
  • Zeggini E; Wellcome Sanger Institute, Cambridge, UK; Institute of Translational Genomics, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
  • Farooqi IS; University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK. Electronic address: isf20@cam.ac.uk.
  • Barroso I; Wellcome Sanger Institute, Cambridge, UK; University of Cambridge MRC Epidemiology Unit, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK. Electronic address: ines.barroso@exeter.ac.uk.
Cell Metab ; 31(6): 1107-1119.e12, 2020 06 02.
Article em En | MEDLINE | ID: mdl-32492392
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pró-Opiomelanocortina / Peptídeos e Proteínas de Sinalização Intracelular / Obesidade Infantil Tipo de estudo: Prognostic_studies Limite: Adult / Animals / Child / Female / Humans / Male / Middle aged Idioma: En Revista: Cell Metab Assunto da revista: METABOLISMO Ano de publicação: 2020 Tipo de documento: Article País de afiliação: França
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pró-Opiomelanocortina / Peptídeos e Proteínas de Sinalização Intracelular / Obesidade Infantil Tipo de estudo: Prognostic_studies Limite: Adult / Animals / Child / Female / Humans / Male / Middle aged Idioma: En Revista: Cell Metab Assunto da revista: METABOLISMO Ano de publicação: 2020 Tipo de documento: Article País de afiliação: França