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Fast spread of COVID-19 in Europe and the US suggests the necessity of early, strong and comprehensive interventions.
Ke, Ruian; Sanche, Steven; Romero-Severson, Ethan; Hengartner, Nick.
Afiliação
  • Ke R; T-6 Theoretical Biology and Biophysics, Theoretical Division, Los Alamos National Laboratory, NM87545, USA.
  • Sanche S; T-6 Theoretical Biology and Biophysics, Theoretical Division, Los Alamos National Laboratory, NM87545, USA.
  • Romero-Severson E; T-CNLS Center for Nonlinear Studies, Los Alamos National Laboratory, NM87545, USA.
  • Hengartner N; T-6 Theoretical Biology and Biophysics, Theoretical Division, Los Alamos National Laboratory, NM87545, USA.
medRxiv ; 2020 Apr 15.
Article em En | MEDLINE | ID: mdl-32511619
The COVID-19 pandemic caused more than 800,000 infections and 40,000 deaths by the end of March 2020. However, some of the basic epidemiological parameters, such as the exponential epidemic growth rate and R0 are debated. We developed an inference approach to control for confounding factors in data collection, such as underreporting and changes in surveillance intensities, and fitted a mathematical model to infection and death count data collected from eight European countries and the US. In all countries, the early epidemic grew exponentially at rates between 0.19-0.29/day (epidemic doubling times between 2.4-3.7 days). This suggests a highly infectious virus with an R0 likely between 4.0 and 7.1. We show that similar levels of intervention efforts are needed, no matter the goal is mitigation or containment. Early, strong and comprehensive intervention efforts to achieve greater than 74-86% reduction in transmission are necessary.

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: MedRxiv Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: MedRxiv Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos