<i>Helicobacter pylori</i> infection downregulates the DNA glycosylase NEIL2, resulting in increased genome damage and inflammation in gastric epithelial cells.

Sayed, Ibrahim M; Sahan, Ayse Z; Venkova, Tatiana; Chakraborty, Anirban; Mukhopadhyay, Dibyabrata; Bimczok, Diane; Beswick, Ellen J; Reyes, Victor E; Pinchuk, Irina; Sahoo, Debashis; Ghosh, Pradipta; Hazra, Tapas K; Das, Soumita

Helicobacter pylori infection downregulates the DNA glycosylase NEIL2, resulting in increased genome damage and inflammation in gastric epithelial cells.

Sayed, Ibrahim M; Sahan, Ayse Z; Venkova, Tatiana; Chakraborty, Anirban; Mukhopadhyay, Dibyabrata; Bimczok, Diane; Beswick, Ellen J; Reyes, Victor E; Pinchuk, Irina; Sahoo, Debashis; Ghosh, Pradipta; Hazra, Tapas K; Das, Soumita.

Afiliação

Sayed IM; Department of Pathology, University of California San Diego, San Diego, California, USA.
Sahan AZ; Department of Pathology, University of California San Diego, San Diego, California, USA.
Venkova T; Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, USA.
Chakraborty A; Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, USA.
Mukhopadhyay D; Department of Pathology, University of California San Diego, San Diego, California, USA.
Bimczok D; Department of Microbiology and Immunology, Montana State University, Bozeman, Montana, USA.
Beswick EJ; Department of Medicine, University of Utah, Salt Lake City, Utah, USA.
Reyes VE; Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas, USA.
Pinchuk I; College of Medicine, Penn State Health Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA.
Sahoo D; Department of Pediatrics, University of California San Diego, San Diego, California, USA.
Ghosh P; Department of Computer Science and Engineering, Jacob's School of Engineering, San Diego, California, USA.
Hazra TK; Department of Medicine and Cellular and Molecular Medicine, John and Rebecca Moore Cancer Center, University of California San Diego, San Diego, California, USA.
Das S; Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, USA sodas@ucsd.edu tkhazra@utmb.edu.

J Biol Chem ; 295(32): 11082-11098, 2020 08 07.

Article em En | MEDLINE | ID: mdl-32518160

Assuntos

DNA Glicosilases/metabolismo; DNA Liase (Sítios Apurínicos ou Apirimidínicos)/metabolismo; Regulação para Baixo; Mucosa Gástrica/metabolismo; Genoma; Infecções por Helicobacter/metabolismo; Helicobacter pylori/isolamento & purificação; Inflamação/metabolismo; Animais; Antígenos de Bactérias/metabolismo; Proteínas de Bactérias/metabolismo; DNA Glicosilases/genética; DNA Liase (Sítios Apurínicos ou Apirimidínicos)/genética; Progressão da Doença; Mucosa Gástrica/patologia; Infecções por Helicobacter/microbiologia; Infecções por Helicobacter/patologia; Helicobacter pylori/metabolismo; Humanos; Camundongos; RNA Mensageiro/genética

Palavras-chave

DNA damage; DNA repair; Helicobacter pylori; Nei-like DNA glycosylase; Nei-like DNA glycosylase 2 (NEIL2); bacterial infection; base excision repair; cytokine response; enteroids; gastric cancer; gastric organoid; infection; inflammation; oxidative stress; stem cells

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação para Baixo / Helicobacter pylori / Infecções por Helicobacter / Genoma / DNA Glicosilases / DNA Liase (Sítios Apurínicos ou Apirimidínicos) / Mucosa Gástrica / Inflamação Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

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