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Synergistic targeting of FLT3 mutations in AML via combined menin-MLL and FLT3 inhibition.
Dzama, Margarita M; Steiner, Marlene; Rausch, Johanna; Sasca, Daniel; Schönfeld, Jonas; Kunz, Kerstin; Taubert, Martha C; McGeehan, Gerard M; Chen, Chun-Wei; Mupo, Annalisa; Hähnel, Patricia; Theobald, Matthias; Kindler, Thomas; Koche, Richard P; Vassiliou, George S; Armstrong, Scott A; Kühn, Michael W M.
Afiliação
  • Dzama MM; Department of Hematology, Medical Oncology, and Pulmonary Medicine, University Medical Center, Johannes Gutenberg-University, Mainz, Germany.
  • Steiner M; Department of Hematology, Medical Oncology, and Pulmonary Medicine, University Medical Center, Johannes Gutenberg-University, Mainz, Germany.
  • Rausch J; German Consortia for Translational Cancer Research, Mainz, Germany.
  • Sasca D; Department of Hematology, Medical Oncology, and Pulmonary Medicine, University Medical Center, Johannes Gutenberg-University, Mainz, Germany.
  • Schönfeld J; German Consortia for Translational Cancer Research, Mainz, Germany.
  • Kunz K; Department of Hematology, Medical Oncology, and Pulmonary Medicine, University Medical Center, Johannes Gutenberg-University, Mainz, Germany.
  • Taubert MC; German Consortia for Translational Cancer Research, Mainz, Germany.
  • McGeehan GM; University Cancer Center Mainz, Mainz, Germany.
  • Chen CW; Department of Hematology, Medical Oncology, and Pulmonary Medicine, University Medical Center, Johannes Gutenberg-University, Mainz, Germany.
  • Mupo A; Department of Hematology, Medical Oncology, and Pulmonary Medicine, University Medical Center, Johannes Gutenberg-University, Mainz, Germany.
  • Hähnel P; Department of Hematology, Medical Oncology, and Pulmonary Medicine, University Medical Center, Johannes Gutenberg-University, Mainz, Germany.
  • Theobald M; Syndax Pharmaceuticals, Inc, Waltham, MA.
  • Kindler T; Department of Systems Biology, Beckman Research Institute, City of Hope, Duarte, CA.
  • Koche RP; Welcome-Medical Research Center (MRC) Cambridge Stem Cell Institute, Department of Haematology, University of Cambridge, Cambridge, United Kingdom.
  • Vassiliou GS; Wellcome Sanger Institute, Cambridge, United Kingdom.
  • Armstrong SA; Department of Hematology, Medical Oncology, and Pulmonary Medicine, University Medical Center, Johannes Gutenberg-University, Mainz, Germany.
  • Kühn MWM; University Cancer Center Mainz, Mainz, Germany.
Blood ; 136(21): 2442-2456, 2020 11 19.
Article em En | MEDLINE | ID: mdl-32589720
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Protocolos de Quimioterapia Combinada Antineoplásica / Regulação Leucêmica da Expressão Gênica / Histona-Lisina N-Metiltransferase / Proteínas Proto-Oncogênicas / Inibidores de Proteínas Quinases / Tirosina Quinase 3 Semelhante a fms / Proteína de Leucina Linfoide-Mieloide / Proteínas de Neoplasias Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Blood Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Protocolos de Quimioterapia Combinada Antineoplásica / Regulação Leucêmica da Expressão Gênica / Histona-Lisina N-Metiltransferase / Proteínas Proto-Oncogênicas / Inibidores de Proteínas Quinases / Tirosina Quinase 3 Semelhante a fms / Proteína de Leucina Linfoide-Mieloide / Proteínas de Neoplasias Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Blood Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Alemanha