eIF3 Associates with 80S Ribosomes to Promote Translation Elongation, Mitochondrial Homeostasis, and Muscle Health.

Lin, Yingying; Li, Fajin; Huang, Linlu; Polte, Christine; Duan, Haoran; Fang, Jianhuo; Sun, Li; Xing, Xudong; Tian, Guiyou; Cheng, Yabin; Ignatova, Zoya; Yang, Xuerui; Wolf, Dieter A

Lin, Yingying; Li, Fajin; Huang, Linlu; Polte, Christine; Duan, Haoran; Fang, Jianhuo; Sun, Li; Xing, Xudong; Tian, Guiyou; Cheng, Yabin; Ignatova, Zoya; Yang, Xuerui; Wolf, Dieter A.

Afiliação

Lin Y; School of Pharmaceutical Sciences, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Xiamen, Fujian 361102, China.
Li F; MOE Key Laboratory of Bioinformatics, Center for Synthetic & Systems Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China; Joint Graduate Program of Peking-Tsinghua-National Institute of Biological Science, Tsinghua University, Beijing 100084, China.
Huang L; School of Pharmaceutical Sciences, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Xiamen, Fujian 361102, China.
Polte C; Biochemistry and Molecular Biology, University of Hamburg, 20146 Hamburg, Germany.
Duan H; School of Pharmaceutical Sciences, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Xiamen, Fujian 361102, China.
Fang J; MOE Key Laboratory of Bioinformatics, Center for Synthetic & Systems Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Sun L; School of Pharmaceutical Sciences, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Xiamen, Fujian 361102, China.
Xing X; MOE Key Laboratory of Bioinformatics, Center for Synthetic & Systems Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China; Joint Graduate Program of Peking-Tsinghua-National Institute of Biological Science, Tsinghua University, Beijing 100084, China.
Tian G; School of Pharmaceutical Sciences, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Xiamen, Fujian 361102, China.
Cheng Y; School of Pharmaceutical Sciences, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Xiamen, Fujian 361102, China; State Key Laboratory of Cellular Stress Biology, Xiamen University, Xiamen, Fujian 361102, China. Electronic address: chengyb@xmu.edu.cn.
Ignatova Z; Biochemistry and Molecular Biology, University of Hamburg, 20146 Hamburg, Germany.
Yang X; MOE Key Laboratory of Bioinformatics, Center for Synthetic & Systems Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China. Electronic address: yangxuerui@tsinghua.edu.cn.
Wolf DA; School of Pharmaceutical Sciences, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Xiamen, Fujian 361102, China; State Key Laboratory of Cellular Stress Biology, Xiamen University, Xiamen, Fujian 361102, China. Electronic address: dwolf@xmu.edu.cn.

Mol Cell ; 79(4): 575-587.e7, 2020 08 20.

Article em En | MEDLINE | ID: mdl-32589965

Assuntos

Fator de Iniciação 3 em Eucariotos/metabolismo; Mitocôndrias/metabolismo; Músculo Esquelético/metabolismo; Elongação Traducional da Cadeia Peptídica; Animais; Membrana Celular/genética; Membrana Celular/metabolismo; Fator de Iniciação 3 em Eucariotos/genética; Células HeLa; Humanos; Camundongos Knockout; Mitocôndrias/genética; Mitocôndrias Musculares/metabolismo; Mitocôndrias Musculares/patologia; Proteínas Mitocondriais/genética; Proteínas Mitocondriais/metabolismo; Músculo Esquelético/patologia; RNA Mensageiro/genética; RNA Mensageiro/metabolismo; Subunidades Ribossômicas/genética; Subunidades Ribossômicas/metabolismo

Palavras-chave

eIF3; knockout mouse; mRNA translation; mitochondrial protein synthesis; muscle strength; ribosome profiling; selective ribosome profiling; translation elongation; translation initiation; translation initiation factor 3

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Elongação Traducional da Cadeia Peptídica / Músculo Esquelético / Fator de Iniciação 3 em Eucariotos / Mitocôndrias Tipo de estudo: Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Mol Cell Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

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