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Nonclinical cardiovascular safety evaluation of romosozumab, an inhibitor of sclerostin for the treatment of osteoporosis in postmenopausal women at high risk of fracture.
Turk, James R; Deaton, Aimee M; Yin, Jun; Stolina, Marina; Felx, Melanie; Boyd, Gabrielle; Bienvenu, Jean-Guy; Varela, Aurore; Guillot, Martin; Holdsworth, Gill; Wolfreys, Alison; Dwyer, Denise; Kumar, Sheetal V; de Koning, Emily M; Qu, Yusheng; Engwall, Michael; Locher, Kathrin; Ward, Lucas D; Glaus, Charles; He, Yudong D; Boyce, Rogely Waite.
Afiliação
  • Turk JR; Translational Safety and Bioanalytical Sciences, Amgen Research, Thousand Oaks, CA, USA. Electronic address: jturk@amgen.com.
  • Deaton AM; Translational Safety and Bioanalytical Sciences, Amgen Research, Cambridge, MA, USA.
  • Yin J; Genome Analysis Unit, Amgen Research, South San Francisco, CA, USA.
  • Stolina M; Cardiometabolic Disorders Research, Amgen Research, Thousand Oaks, CA, USA.
  • Felx M; Charles River Laboratories Montreal ULC, Senneville, QC, Canada.
  • Boyd G; Charles River Laboratories Montreal ULC, Senneville, QC, Canada.
  • Bienvenu JG; Charles River Laboratories Montreal ULC, Senneville, QC, Canada.
  • Varela A; Charles River Laboratories Montreal ULC, Senneville, QC, Canada.
  • Guillot M; Charles River Laboratories Montreal ULC, Senneville, QC, Canada.
  • Holdsworth G; UCB Pharma, Slough, UK.
  • Wolfreys A; UCB Pharma, Slough, UK.
  • Dwyer D; Cardiometabolic Disorders Research, Amgen Research, Thousand Oaks, CA, USA.
  • Kumar SV; Translational Safety and Bioanalytical Sciences, Amgen Research, Cambridge, MA, USA.
  • de Koning EM; Translational Safety and Bioanalytical Sciences, Amgen Research, Cambridge, MA, USA.
  • Qu Y; Translational Safety and Bioanalytical Sciences, Amgen Research, Thousand Oaks, CA, USA.
  • Engwall M; Translational Safety and Bioanalytical Sciences, Amgen Research, Thousand Oaks, CA, USA.
  • Locher K; Translational Safety and Bioanalytical Sciences, Amgen Research, South San Francisco, CA, USA.
  • Ward LD; Translational Safety and Bioanalytical Sciences, Amgen Research, Cambridge, MA, USA.
  • Glaus C; Cardiometabolic Disorders Research, Amgen Research, Thousand Oaks, CA, USA.
  • He YD; Translational Safety and Bioanalytical Sciences, Amgen Research, Thousand Oaks, CA, USA; Genome Analysis Unit, Amgen Research, South San Francisco, CA, USA.
  • Boyce RW; Translational Safety and Bioanalytical Sciences, Amgen Research, Thousand Oaks, CA, USA.
Regul Toxicol Pharmacol ; 115: 104697, 2020 Aug.
Article em En | MEDLINE | ID: mdl-32590049
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistema Cardiovascular / Proteínas Adaptadoras de Transdução de Sinal / Conservadores da Densidade Óssea / Anticorpos Monoclonais Tipo de estudo: Clinical_trials / Etiology_studies / Risk_factors_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Regul Toxicol Pharmacol Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistema Cardiovascular / Proteínas Adaptadoras de Transdução de Sinal / Conservadores da Densidade Óssea / Anticorpos Monoclonais Tipo de estudo: Clinical_trials / Etiology_studies / Risk_factors_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Regul Toxicol Pharmacol Ano de publicação: 2020 Tipo de documento: Article