10H-3,6-Diazaphenothiazines triggered the mitochondrial-dependent and cell death receptor-dependent apoptosis pathways and further increased the chemosensitivity of MCF-7 breast cancer cells via inhibition of AKT1 pathways.

Ren, Guanghui; Hao, Xiaoyan; Yang, Shuyi; Chen, Jun; Qiu, Guobin; Ang, Kok Pian; Mohd Tamrin, Mohd Islahuddin

Ren, Guanghui; Hao, Xiaoyan; Yang, Shuyi; Chen, Jun; Qiu, Guobin; Ang, Kok Pian; Mohd Tamrin, Mohd Islahuddin.

Afiliação

Ren G; Department of General Surgery, Shenzhen Hospital of Southern Medical University, Shenzhen, Guangdong, China.
Hao X; Department of Thyroid and Breast Surgery, Longgang Central Hospital of Shenzhen, Shenzhen, Guangdong, China.
Yang S; Department of General Surgery, Shenzhen Hospital of Southern Medical University, Shenzhen, Guangdong, China.
Chen J; Department of General Surgery, Shenzhen Hospital of Southern Medical University, Shenzhen, Guangdong, China.
Qiu G; Department of General Surgery, Shenzhen Hospital of Southern Medical University, Shenzhen, Guangdong, China.
Ang KP; Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
Mohd Tamrin MI; Department of Surgery, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.

J Biochem Mol Toxicol ; 34(9): e22544, 2020 Sep.

Article em En | MEDLINE | ID: mdl-32619082

Palavras-chave

10H-3,6-Diazaphenothiazine; AKT1 pathways; apoptosis; breast cancer; mitochondrial thioredoxin reductase

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Biochem Mol Toxicol Assunto da revista: BIOLOGIA MOLECULAR / BIOQUIMICA / TOXICOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google