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Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation.
Barbier-Torres, Lucía; Fortner, Karen A; Iruzubieta, Paula; Delgado, Teresa C; Giddings, Emily; Chen, Youdinghuan; Champagne, Devin; Fernández-Ramos, David; Mestre, Daniela; Gomez-Santos, Beatriz; Varela-Rey, Marta; de Juan, Virginia Gutiérrez; Fernández-Tussy, Pablo; Zubiete-Franco, Imanol; García-Monzón, Carmelo; González-Rodríguez, Águeda; Oza, Dhaval; Valença-Pereira, Felipe; Fang, Qian; Crespo, Javier; Aspichueta, Patricia; Tremblay, Frederic; Christensen, Brock C; Anguita, Juan; Martínez-Chantar, María Luz; Rincón, Mercedes.
Afiliação
  • Barbier-Torres L; CIC bioGUNE, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas and Digestivas (CIBERehd). Bizkaia Science and Technology Park, Derio, Bizkaia, Spain.
  • Fortner KA; Department of Medicine, Immunobiology Division, University of Vermont, Burlington, VT, 05405, USA.
  • Iruzubieta P; Department of Gastroenterology and Hepatology, Marqués de Valdecilla University Hospital, Research Institute Marqués de Valdecilla (IDIVAL), Santander, Spain.
  • Delgado TC; CIC bioGUNE, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas and Digestivas (CIBERehd). Bizkaia Science and Technology Park, Derio, Bizkaia, Spain.
  • Giddings E; Department of Medicine, Immunobiology Division, University of Vermont, Burlington, VT, 05405, USA.
  • Chen Y; Departments of Epidemiology, Pharmacology and Toxicology, and Community and Family Medicine, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
  • Champagne D; Department of Medicine, Immunobiology Division, University of Vermont, Burlington, VT, 05405, USA.
  • Fernández-Ramos D; CIC bioGUNE, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas and Digestivas (CIBERehd). Bizkaia Science and Technology Park, Derio, Bizkaia, Spain.
  • Mestre D; Department of Physiology, Faculty of Medicine and Nursing, University of the Basque Country UPB/EHU. Leioa, Biocruces Health Research Institute, Barakaldo, Spain.
  • Gomez-Santos B; Department of Physiology, Faculty of Medicine and Nursing, University of the Basque Country UPB/EHU. Leioa, Biocruces Health Research Institute, Barakaldo, Spain.
  • Varela-Rey M; CIC bioGUNE, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas and Digestivas (CIBERehd). Bizkaia Science and Technology Park, Derio, Bizkaia, Spain.
  • de Juan VG; CIC bioGUNE, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas and Digestivas (CIBERehd). Bizkaia Science and Technology Park, Derio, Bizkaia, Spain.
  • Fernández-Tussy P; CIC bioGUNE, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas and Digestivas (CIBERehd). Bizkaia Science and Technology Park, Derio, Bizkaia, Spain.
  • Zubiete-Franco I; CIC bioGUNE, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas and Digestivas (CIBERehd). Bizkaia Science and Technology Park, Derio, Bizkaia, Spain.
  • García-Monzón C; Liver Research Unit, Santa Cristina University Hospital, Instituto de Investigación Sanitaria Princesa, CIBERehd, Madrid, Spain.
  • González-Rodríguez Á; Liver Research Unit, Santa Cristina University Hospital, Instituto de Investigación Sanitaria Princesa, CIBERehd, Madrid, Spain.
  • Oza D; Alnylam Pharmaceuticals, Cambridge, MA, USA.
  • Valença-Pereira F; Department of Immunology and Microbiology, University of Colorado Denver, Aurora, CO, USA.
  • Fang Q; Department of Immunology and Microbiology, University of Colorado Denver, Aurora, CO, USA.
  • Crespo J; Department of Gastroenterology and Hepatology, Marqués de Valdecilla University Hospital, Research Institute Marqués de Valdecilla (IDIVAL), Santander, Spain.
  • Aspichueta P; Department of Physiology, Faculty of Medicine and Nursing, University of the Basque Country UPB/EHU. Leioa, Biocruces Health Research Institute, Barakaldo, Spain.
  • Tremblay F; Alnylam Pharmaceuticals, Cambridge, MA, USA.
  • Christensen BC; Departments of Epidemiology, Pharmacology and Toxicology, and Community and Family Medicine, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
  • Anguita J; CIC bioGUNE, Inflammation and Macrophage Plasticity laboratory, Bizkaia Science and Technology Park. Derio, Bizkaia, Spain; and Ikerbasque, Basque Foundation for Science, Bilbao, Spain.
  • Martínez-Chantar ML; CIC bioGUNE, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas and Digestivas (CIBERehd). Bizkaia Science and Technology Park, Derio, Bizkaia, Spain.
  • Rincón M; Department of Medicine, Immunobiology Division, University of Vermont, Burlington, VT, 05405, USA. Mercedes.Rincon@cuanschutz.edu.
Nat Commun ; 11(1): 3360, 2020 07 03.
Article em En | MEDLINE | ID: mdl-32620763
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Chaperonas Moleculares / Proteínas Mitocondriais / Proteínas de Choque Térmico HSP40 / Ácidos Graxos / Hepatopatia Gordurosa não Alcoólica / Fígado / Mitocôndrias Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Espanha
Texto completo
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Chaperonas Moleculares / Proteínas Mitocondriais / Proteínas de Choque Térmico HSP40 / Ácidos Graxos / Hepatopatia Gordurosa não Alcoólica / Fígado / Mitocôndrias Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Espanha