Mitochondrial ubiquinol oxidation is necessary for tumour growth.

Martínez-Reyes, Inmaculada; Cardona, Luzivette Robles; Kong, Hyewon; Vasan, Karthik; McElroy, Gregory S; Werner, Marie; Kihshen, Hermon; Reczek, Colleen R; Weinberg, Samuel E; Gao, Peng; Steinert, Elizabeth M; Piseaux, Raul; Budinger, G R Scott; Chandel, Navdeep S

Martínez-Reyes, Inmaculada; Cardona, Luzivette Robles; Kong, Hyewon; Vasan, Karthik; McElroy, Gregory S; Werner, Marie; Kihshen, Hermon; Reczek, Colleen R; Weinberg, Samuel E; Gao, Peng; Steinert, Elizabeth M; Piseaux, Raul; Budinger, G R Scott; Chandel, Navdeep S.

Afiliação

Martínez-Reyes I; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Cardona LR; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Kong H; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Vasan K; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
McElroy GS; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Werner M; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Kihshen H; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Reczek CR; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Weinberg SE; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Gao P; Robert H. Lurie Cancer Center Metabolomics Core, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Steinert EM; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Piseaux R; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Budinger GRS; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Chandel NS; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. nav@northwestern.edu.

Nature ; 585(7824): 288-292, 2020 09.

Article em En | MEDLINE | ID: mdl-32641834

Assuntos

Mitocôndrias/metabolismo; Neoplasias/metabolismo; Neoplasias/patologia; Ubiquinona/análogos & derivados; Animais; Linhagem Celular Tumoral; Proliferação de Células; Ciona intestinalis/enzimologia; Ciclo do Ácido Cítrico; Citosol/metabolismo; Di-Hidro-Orotato Desidrogenase; Transporte de Elétrons; Complexo I de Transporte de Elétrons/metabolismo; Complexo II de Transporte de Elétrons/metabolismo; Complexo III da Cadeia de Transporte de Elétrons/deficiência; Complexo III da Cadeia de Transporte de Elétrons/metabolismo; Humanos; Levilactobacillus brevis/enzimologia; Masculino; Camundongos; Mitocôndrias/enzimologia; Proteínas Mitocondriais/genética; Proteínas Mitocondriais/metabolismo; Complexos Multienzimáticos/genética; Complexos Multienzimáticos/metabolismo; NAD/metabolismo; NADH NADPH Oxirredutases/genética; NADH NADPH Oxirredutases/metabolismo; Neoplasias/enzimologia; Fosforilação Oxidativa; Oxirredutases/genética; Oxirredutases/metabolismo; Oxirredutases atuantes sobre Doadores de Grupo CH-CH/metabolismo; Proteínas de Plantas/genética; Proteínas de Plantas/metabolismo; Ubiquinona/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ubiquinona / Mitocôndrias / Neoplasias Idioma: En Revista: Nature Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

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