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Nox2 activation in Covid-19.
Violi, Francesco; Oliva, Alessandra; Cangemi, Roberto; Ceccarelli, Giancarlo; Pignatelli, Pasquale; Carnevale, Roberto; Cammisotto, Vittoria; Lichtner, Miriam; Alessandri, Francesco; De Angelis, Massimiliano; Miele, Maria Claudia; D'Ettorre, Gabriella; Ruberto, Franco; Venditti, Mario; Pugliese, Francesco; Mastroianni, Claudio Maria.
Afiliação
  • Violi F; Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy. Electronic address: francesco.violi@uniroma1.it.
  • Oliva A; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
  • Cangemi R; Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
  • Ceccarelli G; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
  • Pignatelli P; Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy.
  • Carnevale R; Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy; Mediterranea Cardiocentro, 80122 Napoli, Italy.
  • Cammisotto V; Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy.
  • Lichtner M; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
  • Alessandri F; Department of General Surgery Paride Stefanini, Sapienza University of Rome, Rome, Italy.
  • De Angelis M; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
  • Miele MC; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
  • D'Ettorre G; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
  • Ruberto F; Department of General Surgery Paride Stefanini, Sapienza University of Rome, Rome, Italy.
  • Venditti M; Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy.
  • Pugliese F; Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy.
  • Mastroianni CM; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Redox Biol ; 36: 101655, 2020 09.
Article em En | MEDLINE | ID: mdl-32738789
ABSTRACT
Nox2 is responsible for artery dysfunction via production of reactive oxidant species. RNA viruses may activate Nox2, but it is unknown if this occurs in coronavirus 2019(Covid-19). Nox2 activation by soluble Nox2-derived peptide(sNox2-dp) was measured in patients hospitalized for Covid-19 (n = 182) and controls (n = 91). sNox2-dp values were higher in Covid-19 patients versus controls and in severe versus non severe Covid-19. Patients with thrombotic events(n = 35,19%) had higher sNox2-dp than thrombotic event-free ones. A logistic regression analysis showed that sNox2 and coronary heart disease predicted thrombotic events. Oxidative stress by Nox2 activation is associated severe disease and thrombotic events in Covid-19 patients.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pneumonia Viral / Trombose / Infecções por Coronavirus / NADPH Oxidase 2 Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Redox Biol Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pneumonia Viral / Trombose / Infecções por Coronavirus / NADPH Oxidase 2 Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Redox Biol Ano de publicação: 2020 Tipo de documento: Article