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An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene.
Roubroeks, Janou A Y; Smith, Adam R; Smith, Rebecca G; Pishva, Ehsan; Ibrahim, Zina; Sattlecker, Martina; Hannon, Eilis J; Kloszewska, Iwona; Mecocci, Patrizia; Soininen, Hilkka; Tsolaki, Magda; Vellas, Bruno; Wahlund, Lars-Olof; Aarsland, Dag; Proitsi, Petroula; Hodges, Angela; Lovestone, Simon; Newhouse, Stephen J; Dobson, Richard J B; Mill, Jonathan; van den Hove, Daniël L A; Lunnon, Katie.
Afiliação
  • Roubroeks JAY; College of Medicine and Health, University of Exeter, Exeter, UK.
  • Smith AR; College of Medicine and Health, University of Exeter, Exeter, UK.
  • Smith RG; College of Medicine and Health, University of Exeter, Exeter, UK.
  • Pishva E; College of Medicine and Health, University of Exeter, Exeter, UK; School for Mental Health and Neuroscience (MHeNS), Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, the Netherlands.
  • Ibrahim Z; Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience (IOPPN), King's College London, London, UK; Farr Institute of Health Informatics Research, University College London, London, UK.
  • Sattlecker M; Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience (IOPPN), King's College London, London, UK.
  • Hannon EJ; College of Medicine and Health, University of Exeter, Exeter, UK.
  • Kloszewska I; Medical University of Lodz, Lodz, Poland.
  • Mecocci P; Institute of Gerontology and Geriatrics, University of Perugia, Perugia, Italy.
  • Soininen H; Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland; Neurocenter, Neurology, Kuopio University Hospital, Kuopio, Finland.
  • Tsolaki M; 1st Department of Neurology, Memory and Dementia Unit, Aristotle University of Thessaloniki, Thessaloniki, Greece.
  • Vellas B; INSERM U 558, University of Toulouse, Toulouse, France.
  • Wahlund LO; NVS Department, Section for Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden.
  • Aarsland D; King's Health Partners Centre for Neurodegeneration Research, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; Centre for Age-Related Diseases, Stavanger University Hospital, Stavanger, Norway.
  • Proitsi P; King's Health Partners Centre for Neurodegeneration Research, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; NIHR Biomedical Research Centre for Mental Health at South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, King's College Londo
  • Hodges A; King's Health Partners Centre for Neurodegeneration Research, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Lovestone S; Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK; Current Affiliation at Janssen-Cilag UK.
  • Newhouse SJ; King's Health Partners Centre for Neurodegeneration Research, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; NIHR Biomedical Research Centre for Mental Health at South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, King's College Londo
  • Dobson RJB; Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience (IOPPN), King's College London, London, UK; Farr Institute of Health Informatics Research, University College London, London, UK.
  • Mill J; College of Medicine and Health, University of Exeter, Exeter, UK.
  • van den Hove DLA; School for Mental Health and Neuroscience (MHeNS), Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, the Netherlands; Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Würzburg, Germany.
  • Lunnon K; College of Medicine and Health, University of Exeter, Exeter, UK. Electronic address: k.lunnon@exeter.ac.uk.
Neurobiol Aging ; 95: 26-45, 2020 11.
Article em En | MEDLINE | ID: mdl-32745807
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Homeodomínio / Metilação de DNA / Estudo de Associação Genômica Ampla / Doença de Alzheimer Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Neurobiol Aging Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Homeodomínio / Metilação de DNA / Estudo de Associação Genômica Ampla / Doença de Alzheimer Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Neurobiol Aging Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Reino Unido