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Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity.
Mahy, William; Patel, Mikesh; Steadman, David; Woodward, Hannah L; Atkinson, Benjamin N; Svensson, Fredrik; Willis, Nicky J; Flint, Alister; Papatheodorou, Dimitra; Zhao, Yuguang; Vecchia, Luca; Ruza, Reinis R; Hillier, James; Frew, Sarah; Monaghan, Amy; Costa, Artur; Bictash, Magda; Walter, Magnus W; Jones, E Yvonne; Fish, Paul V.
Afiliação
  • Mahy W; Alzheimer's Research UK UCL Drug Discovery Institute, University College London, Cruciform Building, Gower Street, London WC1E 6BT, United Kingdom.
  • Patel M; Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, United Kingdom.
  • Steadman D; Alzheimer's Research UK UCL Drug Discovery Institute, University College London, Cruciform Building, Gower Street, London WC1E 6BT, United Kingdom.
  • Woodward HL; Alzheimer's Research UK UCL Drug Discovery Institute, University College London, Cruciform Building, Gower Street, London WC1E 6BT, United Kingdom.
  • Atkinson BN; Alzheimer's Research UK UCL Drug Discovery Institute, University College London, Cruciform Building, Gower Street, London WC1E 6BT, United Kingdom.
  • Svensson F; Alzheimer's Research UK UCL Drug Discovery Institute, University College London, Cruciform Building, Gower Street, London WC1E 6BT, United Kingdom.
  • Willis NJ; The Francis Crick Institute, 1 Midland Road, Kings Cross, London NW1 1AT, United Kingdom.
  • Flint A; Alzheimer's Research UK UCL Drug Discovery Institute, University College London, Cruciform Building, Gower Street, London WC1E 6BT, United Kingdom.
  • Papatheodorou D; Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, United Kingdom.
  • Zhao Y; UCL School of Pharmacy, University College London, 29-39 Brunswick Square, Bloomsbury, London WC1N 1AX, United Kingdom.
  • Vecchia L; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, The Henry Wellcome Building for Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, United Kingdom.
  • Ruza RR; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, The Henry Wellcome Building for Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, United Kingdom.
  • Hillier J; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, The Henry Wellcome Building for Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, United Kingdom.
  • Frew S; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, The Henry Wellcome Building for Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, United Kingdom.
  • Monaghan A; Alzheimer's Research UK UCL Drug Discovery Institute, University College London, Cruciform Building, Gower Street, London WC1E 6BT, United Kingdom.
  • Costa A; Alzheimer's Research UK UCL Drug Discovery Institute, University College London, Cruciform Building, Gower Street, London WC1E 6BT, United Kingdom.
  • Bictash M; Alzheimer's Research UK UCL Drug Discovery Institute, University College London, Cruciform Building, Gower Street, London WC1E 6BT, United Kingdom.
  • Walter MW; Alzheimer's Research UK UCL Drug Discovery Institute, University College London, Cruciform Building, Gower Street, London WC1E 6BT, United Kingdom.
  • Jones EY; Eli Lilly, Erl Wood Manor, Windlesham, Surrey GU20 6PH, United Kingdom.
  • Fish PV; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, The Henry Wellcome Building for Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, United Kingdom.
J Med Chem ; 63(17): 9464-9483, 2020 09 10.
Article em En | MEDLINE | ID: mdl-32787107
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirróis / Pirrolidinas / Hidrolases de Éster Carboxílico / Inibidores Enzimáticos Tipo de estudo: Diagnostic_studies / Screening_studies Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirróis / Pirrolidinas / Hidrolases de Éster Carboxílico / Inibidores Enzimáticos Tipo de estudo: Diagnostic_studies / Screening_studies Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Reino Unido