Ritonavir associated maculopathy- multimodal imaging and electrophysiology findings.
Am J Ophthalmol Case Rep
; 19: 100783, 2020 Sep.
Article
em En
| MEDLINE
| ID: mdl-32803017
ABSTRACT
PURPOSE:
To report the case 47-year-old patient presenting with severe maculopathy associated with long-term ritonavir treatment.METHODS:
Observational case report of one patient and literature review.RESULTS:
A 47 year-old Caucasian man presented with progressive bilateral vision loss for the past 5 years. His medical history included Human Immunodeficiency Virus (HIV) and Hepatitis C Virus (HCV) coinfection since 1992. He was treated by highly active antiretroviral therapy for 24 years including 4 years of didanosine treatment and 18 years of ritonavir treatment. Bilateral extensive macular atrophy with foveal sparing on the left eye and absence of midperipheral/peripheral retina involvement was confirmed on multimodal imaging and functional testing including swept-source OCT angiography and electroretinography.CONCLUSION:
Ritonavir associated maculopathy is a scarcely described medication-associated retinopathy. In this case, an extensive macular atrophy (with complete loss of photoreceptor, RPE and choriocapillaris layers) and subsequent cone-rod dysfunction appeared after 18 years of ritonavir exposure.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Diagnostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Am J Ophthalmol Case Rep
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
França