Accelerated, severe lupus nephritis benefits from treatment with honokiol by immunoregulation and differentially regulating NF-&#954;B/NLRP3 inflammasome and sirtuin 1/autophagy axis.

Yang, Shin-Ruen; Hsu, Wan-Han; Wu, Chung-Yao; Shang, Hung-Sheng; Liu, Feng-Cheng; Chen, Ann; Hua, Kuo-Feng; Ka, Shuk-Man

Accelerated, severe lupus nephritis benefits from treatment with honokiol by immunoregulation and differentially regulating NF-κB/NLRP3 inflammasome and sirtuin 1/autophagy axis.

Yang, Shin-Ruen; Hsu, Wan-Han; Wu, Chung-Yao; Shang, Hung-Sheng; Liu, Feng-Cheng; Chen, Ann; Hua, Kuo-Feng; Ka, Shuk-Man.

Afiliação

Yang SR; Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan.
Hsu WH; Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Wu CY; Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan.
Shang HS; Division of Clinical Pathology, Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Liu FC; Division of Rheumatology/Immunology and Allergy, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Chen A; Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Hua KF; Department of Biotechnology and Animal Science, National Ilan University, Ilan, Taiwan.
Ka SM; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan.

FASEB J ; 34(10): 13284-13299, 2020 10.

Article em En | MEDLINE | ID: mdl-32813287

Assuntos

Anti-Inflamatórios/uso terapêutico; Autofagia; Compostos de Bifenilo/uso terapêutico; Inflamassomos/metabolismo; Lignanas/uso terapêutico; Nefrite Lúpica/tratamento farmacológico; NF-kappa B/metabolismo; Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo; Animais; Células Cultivadas; Feminino; Inflamassomos/efeitos dos fármacos; Rim/efeitos dos fármacos; Rim/metabolismo; Nefrite Lúpica/metabolismo; Camundongos; Espécies Reativas de Oxigênio/metabolismo; Sirtuína 1/metabolismo; Linfócitos T/efeitos dos fármacos

Palavras-chave

NLRP3 inflammasome; accelerated; autophagy; honokiol; severe lupus nephritis; sirtuin 1

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autofagia / Compostos de Bifenilo / Nefrite Lúpica / NF-kappa B / Lignanas / Inflamassomos / Proteína 3 que Contém Domínio de Pirina da Família NLR / Anti-Inflamatórios Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: FASEB J Assunto da revista: BIOLOGIA / FISIOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Taiwan

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