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Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.
Jia, Na; Wang, Jinfeng; Shi, Wenqiang; Du, Lifeng; Sun, Yi; Zhan, Wei; Jiang, Jia-Fu; Wang, Qian; Zhang, Bing; Ji, Peifeng; Bell-Sakyi, Lesley; Cui, Xiao-Ming; Yuan, Ting-Ting; Jiang, Bao-Gui; Yang, Wei-Fei; Lam, Tommy Tsan-Yuk; Chang, Qiao-Cheng; Ding, Shu-Jun; Wang, Xian-Jun; Zhu, Jin-Guo; Ruan, Xiang-Dong; Zhao, Lin; Wei, Jia-Te; Ye, Run-Ze; Que, Teng Cheng; Du, Chun-Hong; Zhou, Yu-Hao; Cheng, Jing Xia; Dai, Pei-Fang; Guo, Wen-Bin; Han, Xiao-Hu; Huang, En-Jiong; Li, Lian-Feng; Wei, Wei; Gao, Yu-Chi; Liu, Jing-Ze; Shao, Hong-Ze; Wang, Xin; Wang, Chong-Cai; Yang, Tian-Ci; Huo, Qiu-Bo; Li, Wei; Chen, Hai-Ying; Chen, Shen-En; Zhou, Ling-Guo; Ni, Xue-Bing; Tian, Jun-Hua; Sheng, Yue; Liu, Tao; Pan, Yu-Sheng.
Afiliação
  • Jia N; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, P.R. China; Research Unit of Discovery and Tracing of Natural Focus Diseases, Chinese Academy of Medical Sciences, Beijing 100071, P.R. China.
  • Wang J; Computational Genomics Lab, Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, P.R. China; State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, P.R. China.
  • Shi W; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, P.R. China.
  • Du L; Computational Genomics Lab, Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, P.R. China; Institute of EcoHealth, School of Public Health, Shandong University, 44 Wenhuaxi Street, Jinan 250012, Shandong, P.R. China.
  • Sun Y; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, P.R. China.
  • Zhan W; Annoroad Gene Technology (Beijing) Company Limited, Beijing 100176, P.R. China.
  • Jiang JF; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, P.R. China; Research Unit of Discovery and Tracing of Natural Focus Diseases, Chinese Academy of Medical Sciences, Beijing 100071, P.R. China.
  • Wang Q; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, P.R. China; Institute of EcoHealth, School of Public Health, Shandong University, 44 Wenhuaxi Street, Jinan 250012, Shandong, P.R. China.
  • Zhang B; Computational Genomics Lab, Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, P.R. China.
  • Ji P; Computational Genomics Lab, Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, P.R. China.
  • Bell-Sakyi L; Department of Infection Biology and Microbiomes, Institute of Infection, Ecological and Veterinary Sciences, University of Liverpool, Liverpool L3 5RF, UK.
  • Cui XM; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, P.R. China; Research Unit of Discovery and Tracing of Natural Focus Diseases, Chinese Academy of Medical Sciences, Beijing 100071, P.R. China.
  • Yuan TT; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, P.R. China.
  • Jiang BG; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, P.R. China.
  • Yang WF; Annoroad Gene Technology (Beijing) Company Limited, Beijing 100176, P.R. China.
  • Lam TT; State Key Laboratory of Emerging Infectious Diseases and Centre of Influenza Research, School of Public Health, The University of Hong Kong, Hong Kong SAR, China.
  • Chang QC; College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing 163319, Heilongjiang, P.R. China.
  • Ding SJ; Shandong Center for Disease Control and Prevention, Shandong Provincial Key Laboratory of Communicable Disease Control and Prevention, Jinan 250014, Shandong, P.R. China.
  • Wang XJ; Shandong Center for Disease Control and Prevention, Shandong Provincial Key Laboratory of Communicable Disease Control and Prevention, Jinan 250014, Shandong, P.R. China.
  • Zhu JG; ManZhouLi Customs District, Manzhouli 021400, Inner Mongolia, P.R. China.
  • Ruan XD; Academy of Forest Inventory and Planning, State Forestry and Grassland Administration, Beijing 100714, P.R. China.
  • Zhao L; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, P.R. China; Institute of EcoHealth, School of Public Health, Shandong University, 44 Wenhuaxi Street, Jinan 250012, Shandong, P.R. China.
  • Wei JT; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, P.R. China; Institute of EcoHealth, School of Public Health, Shandong University, 44 Wenhuaxi Street, Jinan 250012, Shandong, P.R. China.
  • Ye RZ; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, P.R. China; Institute of EcoHealth, School of Public Health, Shandong University, 44 Wenhuaxi Street, Jinan 250012, Shandong, P.R. China.
  • Que TC; Guangxi Zhuang Autonomous Region Terrestrial Wildlife Medical-aid and Monitoring Epidemic Diseases Research Center, Nanjing 530028, Guangxi, P.R. China.
  • Du CH; Yunnan Institute for Endemic Diseases Control and Prevention, Dali 671000, Yunnan, P.R. China.
  • Zhou YH; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, P.R. China.
  • Cheng JX; Shanxi Provence Center for Disease Control and Prevention, Xian 030012, Shanxi, P.R. China.
  • Dai PF; Shanxi Provence Center for Disease Control and Prevention, Xian 030012, Shanxi, P.R. China.
  • Guo WB; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, P.R. China.
  • Han XH; Shenyang Agriculture University, Shenyang 110866, Liaoning, P.R. China.
  • Huang EJ; Fuzhou International Travel Healthcare Center, Fuzhou 350001, Fujian, P.R. China.
  • Li LF; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, P.R. China.
  • Wei W; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, P.R. China.
  • Gao YC; Annoroad Gene Technology (Beijing) Company Limited, Beijing 100176, P.R. China.
  • Liu JZ; Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology of Hebei Province, College of Life Sciences, Hebei Normal University, Shijiazhuang 050024, Hebei, P.R. China.
  • Shao HZ; Animal Husbandry and Veterinary Science Research Institute of Jilin Province, Changchun 130062, Jilin, P.R. China.
  • Wang X; Qingjiangpu District Center for Disease Control and Prevention, Huai'an 223001, Jiangsu, P.R. China.
  • Wang CC; Hainan International Travel Healthcare Center, Haikou 570311, Hainan, P.R. China.
  • Yang TC; State Key Lab of Mosquito-borne Diseases, Hangzhou International Tourism Healthcare Center, Hangzhou Customs of China, Hangzhou 310012, Zhejiang, P.R. China.
  • Huo QB; Mudanjiang Forestry Central Hospital, Mudanjiang 157000, Heilongjiang, P.R. China.
  • Li W; Xinjiang Center for Disease Control and Prevention, Urumqi 830002, Xinjiang, P.R. China.
  • Chen HY; Collaboration Unit for Field Epidemiology of the State Key Laboratory for Infectious Disease Prevention and Control, Nanchang Center for Disease Control and Prevention. Nanchang 330038, Jiangxi, P.R. China.
  • Chen SE; Collaboration Unit for Field Epidemiology of the State Key Laboratory for Infectious Disease Prevention and Control, Nanchang Center for Disease Control and Prevention. Nanchang 330038, Jiangxi, P.R. China.
  • Zhou LG; Shaanxi Natural Reserve and Wildlife Administration Station, Xi'an 710082, Shaanxi, P.R. China.
  • Ni XB; State Key Laboratory of Emerging Infectious Diseases and Centre of Influenza Research, School of Public Health, The University of Hong Kong, Hong Kong SAR, China.
  • Tian JH; Wuhan Center for Disease Control and Prevention, Wuhan 430015, Hubei, P.R. China.
  • Sheng Y; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, P.R. China.
  • Liu T; Annoroad Gene Technology (Beijing) Company Limited, Beijing 100176, P.R. China.
  • Pan YS; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, P.R. China.
Cell ; 182(5): 1328-1340.e13, 2020 09 03.
Article em En | MEDLINE | ID: mdl-32814014
ABSTRACT
Among arthropod vectors, ticks transmit the most diverse human and animal pathogens, leading to an increasing number of new challenges worldwide. Here we sequenced and assembled high-quality genomes of six ixodid tick species and further resequenced 678 tick specimens to understand three key aspects of ticks genetic diversity, population structure, and pathogen distribution. We explored the genetic basis common to ticks, including heme and hemoglobin digestion, iron metabolism, and reactive oxygen species, and unveiled for the first time that genetic structure and pathogen composition in different tick species are mainly shaped by ecological and geographic factors. We further identified species-specific determinants associated with different host ranges, life cycles, and distributions. The findings of this study are an invaluable resource for research and control of ticks and tick-borne diseases.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carrapatos / Variação Genética / Doenças Transmitidas por Carrapatos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Cell Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carrapatos / Variação Genética / Doenças Transmitidas por Carrapatos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Cell Ano de publicação: 2020 Tipo de documento: Article