Chronic small airway disease in the horse: immunohistochemical evaluation of lungs with mild, moderate and severe lesions.
Vet Rec
; 122(8): 181-3, 1988 Feb 20.
Article
em En
| MEDLINE
| ID: mdl-3282389
ABSTRACT
The peroxidase anti-peroxidase technique was used to demonstrate free and intracellular immunoglobulin (Ig) within the lungs of 23 horses with chronic small airway disease. Histologically, all the horses had chronic bronchiolitis; however, the lesions varied in degree from mild in eight horses, to moderate in nine horses and severe in six horses. Lungs from three horses which had no gross or histopathological lesions were used as controls. In comparison with control horses, horses with mild chronic bronchiolitis had increased numbers of Ig A-containing and non-immunoglobulin staining cells around the vasculature and bronchioles. As the severity of the lesions increased so did the number of IgA-, IgG(Fc)- and in several cases non-immunoglobulin staining cells around the vasculature, bronchioles and in the alveolar septa. In severely affected horses, large amounts of free IgG(Fc) were observed interstitially and in alveoli. In areas of mucosal epithelial hyperplasia and metaplasia large amounts of free IgA and IgG(Fc) were sometimes observed interepithelially in a pattern which differed from that in control horses.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bronquiolite
/
Doenças dos Cavalos
/
Pulmão
Limite:
Animals
Idioma:
En
Revista:
Vet Rec
Ano de publicação:
1988
Tipo de documento:
Article