Quadruple abnormal protein aggregates in brainstem pathology and exogenous metal-rich magnetic nanoparticles (and engineered Ti-rich nanorods). The substantia nigrae is a very early target in young urbanites and the gastrointestinal tract a key brainstem portal.

Calderón-Garcidueñas, Lilian; González-Maciel, Angélica; Reynoso-Robles, Rafael; Hammond, Jessica; Kulesza, Randy; Lachmann, Ingolf; Torres-Jardón, Ricardo; Mukherjee, Partha S; Maher, Barbara A

Calderón-Garcidueñas, Lilian; González-Maciel, Angélica; Reynoso-Robles, Rafael; Hammond, Jessica; Kulesza, Randy; Lachmann, Ingolf; Torres-Jardón, Ricardo; Mukherjee, Partha S; Maher, Barbara A.

Afiliação

Calderón-Garcidueñas L; The University of Montana, Missoula, MT, 59812, USA; Universidad del Valle de México, 14370, Mexico. Electronic address: lilian.calderon-garciduenas@umontana.edu.
González-Maciel A; Instituto Nacional de Pediatría, 04530, Mexico.
Reynoso-Robles R; Instituto Nacional de Pediatría, 04530, Mexico.
Hammond J; Centre for Environmental Magnetism and Paleomagnetism, Lancaster Environment Centre, University of Lancaster, Lancaster, LA1 4YQ, UK.
Kulesza R; Auditory Research Center, Lake Erie College of Osteopathic Medicine, Erie, PA, USA.
Lachmann I; AJ Roboscreen GmbH, Leipzig, 04129, Germany.
Torres-Jardón R; Centro de Ciencias de la Atmósfera, Universidad Nacional Autónoma de México, UNAM, Mexico City, 04510, Mexico.
Mukherjee PS; Indian Statistical Institute, Kolkata, 700108, India.
Maher BA; Centre for Environmental Magnetism and Paleomagnetism, Lancaster Environment Centre, University of Lancaster, Lancaster, LA1 4YQ, UK.

Environ Res ; 191: 110139, 2020 12.

Article em En | MEDLINE | ID: mdl-32888951

Assuntos

Doença de Alzheimer; Nanopartículas de Magnetita; Nanotubos; Tronco Encefálico; Criança; Cidades; Trato Gastrointestinal; Humanos; México; Agregados Proteicos; Titânio/toxicidade; Adulto Jovem; alfa-Sinucleína

Palavras-chave

Alpha-synucleinopathies; Aluminum; Alzheimer; Brainstem; Cerebellum; Children; Energy-dispersive X ray analysis EDX; High resolution scanning TEM; Hyperphosphorylated tau pτ; Iron; Magnetite; Mexico City; Nanoparticles; Neuroenteric system; Neuromelanin; PM(2.5,) portal of entry; Parkinson disease; Protein misfolding; Substantia nigrae; TDP-43 proteinopathies; tauopathies, titanium,Ti-rich nanorods; α-Syn

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nanotubos / Nanopartículas de Magnetita / Doença de Alzheimer Tipo de estudo: Prognostic_studies Limite: Adult / Child / Humans País/Região como assunto: Mexico Idioma: En Revista: Environ Res Ano de publicação: 2020 Tipo de documento: Article

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