Nineteen New Flavanol-Fatty Alcohol Hybrids with &#945;-Glucosidase and PTP1B Dual Inhibition: One Unusual Type of Antidiabetic Constituent from <i>Amomum tsao-ko</i>.

He, Xiao-Feng; Chen, Ji-Jun; Li, Tian-Ze; Zhang, Xu-Ke; Guo, Yuan-Qiang; Zhang, Xue-Mei; Hu, Jing; Geng, Chang-An

Nineteen New Flavanol-Fatty Alcohol Hybrids with α-Glucosidase and PTP1B Dual Inhibition: One Unusual Type of Antidiabetic Constituent from Amomum tsao-ko.

He, Xiao-Feng; Chen, Ji-Jun; Li, Tian-Ze; Zhang, Xu-Ke; Guo, Yuan-Qiang; Zhang, Xue-Mei; Hu, Jing; Geng, Chang-An.

Afiliação

He XF; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Yunnan Key Laboratory of Natural Medicinal Chemistry, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
Chen JJ; University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
Li TZ; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Yunnan Key Laboratory of Natural Medicinal Chemistry, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
Zhang XK; University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
Guo YQ; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Yunnan Key Laboratory of Natural Medicinal Chemistry, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
Zhang XM; College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, People's Republic of China.
Hu J; College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, People's Republic of China.
Geng CA; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Yunnan Key Laboratory of Natural Medicinal Chemistry, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.

J Agric Food Chem ; 68(41): 11434-11448, 2020 Oct 14.

Article em En | MEDLINE | ID: mdl-32965110

Assuntos

Amomum/química; Álcoois Graxos/química; Flavanonas/química; Inibidores de Glicosídeo Hidrolases/química; Hipoglicemiantes/química; Extratos Vegetais/química; Proteína Tirosina Fosfatase não Receptora Tipo 1/antagonistas & inibidores; Álcoois Graxos/isolamento & purificação; Flavanonas/isolamento & purificação; Frutas/química; Inibidores de Glicosídeo Hidrolases/isolamento & purificação; Humanos; Hipoglicemiantes/isolamento & purificação; Extratos Vegetais/isolamento & purificação; Proteína Tirosina Fosfatase não Receptora Tipo 1/química; alfa-Glucosidases/química

Palavras-chave

Amomum tsao-ko; PTP1B/TCPTP selective inhibitors; antidiabetic effects; tsaokoflavanols A−S; α-glucosidase inhibitors

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Amomum / Flavanonas / Proteína Tirosina Fosfatase não Receptora Tipo 1 / Álcoois Graxos / Inibidores de Glicosídeo Hidrolases / Hipoglicemiantes Limite: Humans Idioma: En Revista: J Agric Food Chem Ano de publicação: 2020 Tipo de documento: Article

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