Metabolic Consequences of Supplemented Methionine in a Clinical Context.
J Nutr
; 150(Suppl 1): 2538S-2547S, 2020 10 01.
Article
em En
| MEDLINE
| ID: mdl-33000166
ABSTRACT
The central position of methionine (Met) in protein metabolism indicates the importance of this essential amino acid for growth and maintenance of lean body mass. Therefore, Met might be a tempting candidate for supplementation. However, because Met is also the precursor of homocysteine (Hcy), a deficient intake of B vitamins or excessive intake of Met may result in hyperhomocysteinemia (HHcy), which is a risk factor for cardiovascular disease. This review discusses the evidence generated in preclinical and clinical studies on the importance and potentially harmful effects of Met supplementation and elaborates on potential clinical applications of supplemental Met with reference to clinical studies performed over the past 20 y. Recently acquired knowledge about the NOAEL (no observed adverse effect level) of 46.3 mg · kg-1 · d-1 and the LOAEL (lowest observed adverse effect level) of 91 mg · kg-1 · d-1 of supplemented Met will guide the design of future studies to further establish the role of Met as a potential (safe) candidate for nutritional supplementation in clinical applications.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Deficiência de Vitaminas do Complexo B
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Compartimentos de Líquidos Corporais
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Doenças Cardiovasculares
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Suplementos Nutricionais
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Hiper-Homocisteinemia
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Homocisteína
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Metionina
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
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Female
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Humans
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Male
Idioma:
En
Revista:
J Nutr
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Estados Unidos