Recombinant <i>Bacillus caldovelox</i> Arginase Mutant (BCA-M) Induces Apoptosis, Autophagy, Cell Cycle Arrest and Growth Inhibition in Human Cervical Cancer Cells.

Chung, Sai-Fung; Kim, Chi-Fai; Chow, Ho-Yin; Chong, Hiu-Chi; Tam, Suet-Ying; Leung, Yun-Chung; Lo, Wai-Hung

Recombinant Bacillus caldovelox Arginase Mutant (BCA-M) Induces Apoptosis, Autophagy, Cell Cycle Arrest and Growth Inhibition in Human Cervical Cancer Cells.

Chung, Sai-Fung; Kim, Chi-Fai; Chow, Ho-Yin; Chong, Hiu-Chi; Tam, Suet-Ying; Leung, Yun-Chung; Lo, Wai-Hung.

Afiliação

Chung SF; Department of Applied Biology and Chemical Technology, Lo Ka Chung Research Centre for Natural Anti-Cancer Drug Development and State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.
Kim CF; Department of Applied Biology and Chemical Technology, Lo Ka Chung Research Centre for Natural Anti-Cancer Drug Development and State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.
Chow HY; Department of Applied Biology and Chemical Technology, Lo Ka Chung Research Centre for Natural Anti-Cancer Drug Development and State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.
Chong HC; Department of Applied Biology and Chemical Technology, Lo Ka Chung Research Centre for Natural Anti-Cancer Drug Development and State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.
Tam SY; Department of Applied Biology and Chemical Technology, Lo Ka Chung Research Centre for Natural Anti-Cancer Drug Development and State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.
Leung YC; Department of Applied Biology and Chemical Technology, Lo Ka Chung Research Centre for Natural Anti-Cancer Drug Development and State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.
Lo WH; Department of Applied Biology and Chemical Technology, Lo Ka Chung Research Centre for Natural Anti-Cancer Drug Development and State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.

Int J Mol Sci ; 21(20)2020 Oct 09.

Article em En | MEDLINE | ID: mdl-33050217

Assuntos

Antineoplásicos/farmacologia; Apoptose/efeitos dos fármacos; Arginase/farmacologia; Autofagia/efeitos dos fármacos; Pontos de Checagem do Ciclo Celular/efeitos dos fármacos; Geobacillus/enzimologia; Proteínas Recombinantes/farmacologia; Arginase/genética; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Sinergismo Farmacológico; Feminino; Perfilação da Expressão Gênica; Geobacillus/genética; Humanos; Redes e Vias Metabólicas/efeitos dos fármacos; Proteínas Mutantes; Proteínas Recombinantes/genética; Ureia/metabolismo; Neoplasias do Colo do Útero/tratamento farmacológico; Neoplasias do Colo do Útero/genética; Neoplasias do Colo do Útero/metabolismo; Neoplasias do Colo do Útero/patologia

Palavras-chave

apoptosis; arginase; autophagy; cell cycle arrest; cervical cancer cell

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Arginase / Autofagia / Proteínas Recombinantes / Apoptose / Geobacillus / Pontos de Checagem do Ciclo Celular / Antineoplásicos Tipo de estudo: Clinical_trials Limite: Female / Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

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