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First Phylogenetic Analysis of Malian SARS-CoV-2 Sequences Provides Molecular Insights into the Genomic Diversity of the Sahel Region.
Kouriba, Bourema; Dürr, Angela; Rehn, Alexandra; Sangaré, Abdoul Karim; Traoré, Brehima Y; Bestehorn-Willmann, Malena S; Ouedraogo, Judicael; Heitzer, Asli; Sogodogo, Elisabeth; Maiga, Abderrhamane; Walter, Mathias C; Zimmermann, Fee; Wölfel, Roman; Antwerpen, Markus H.
Afiliação
  • Kouriba B; Centre d'Infectiologie Charles Mérieux du Mali, Bamako BPE2283, Mali.
  • Dürr A; Bundeswehr Institute of Microbiology, D-80937 Munich, Germany.
  • Rehn A; Bundeswehr Institute of Microbiology, D-80937 Munich, Germany.
  • Sangaré AK; Centre d'Infectiologie Charles Mérieux du Mali, Bamako BPE2283, Mali.
  • Traoré BY; Centre d'Infectiologie Charles Mérieux du Mali, Bamako BPE2283, Mali.
  • Bestehorn-Willmann MS; Bundeswehr Institute of Microbiology, D-80937 Munich, Germany.
  • Ouedraogo J; Centre d'Infectiologie Charles Mérieux du Mali, Bamako BPE2283, Mali.
  • Heitzer A; Bundeswehr Institute of Microbiology, D-80937 Munich, Germany.
  • Sogodogo E; Centre d'Infectiologie Charles Mérieux du Mali, Bamako BPE2283, Mali.
  • Maiga A; Centre d'Infectiologie Charles Mérieux du Mali, Bamako BPE2283, Mali.
  • Walter MC; Bundeswehr Institute of Microbiology, D-80937 Munich, Germany.
  • Zimmermann F; Bundeswehr Institute of Microbiology, D-80937 Munich, Germany.
  • Wölfel R; Bundeswehr Institute of Microbiology, D-80937 Munich, Germany.
  • Antwerpen MH; Bundeswehr Institute of Microbiology, D-80937 Munich, Germany.
Viruses ; 12(11)2020 11 02.
Article em En | MEDLINE | ID: mdl-33147840
ABSTRACT
We are currently facing a pandemic of COVID-19, caused by a spillover from an animal-originating coronavirus to humans occurring in the Wuhan region of China in December 2019. From China, the virus has spread to 188 countries and regions worldwide, reaching the Sahel region on March 2, 2020. Since whole genome sequencing (WGS) data is very crucial to understand the spreading dynamics of the ongoing pandemic, but only limited sequencing data is available from the Sahel region to date, we have focused our efforts on generating the first Malian sequencing data available. Screening 217 Malian patient samples for the presence of SARS-CoV-2 resulted in 38 positive isolates, from which 21 whole genome sequences were generated. Our analysis shows that both the early A (19B) and the later observed B (20A/C) clade are present in Mali, indicating multiple and independent introductions of SARS-CoV-2 to the Sahel region.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pneumonia Viral / RNA Viral / Genoma Viral / Infecções por Coronavirus / Betacoronavirus Limite: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Female / Humans / Male / Middle aged País/Região como assunto: Africa Idioma: En Revista: Viruses Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Mali

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pneumonia Viral / RNA Viral / Genoma Viral / Infecções por Coronavirus / Betacoronavirus Limite: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Female / Humans / Male / Middle aged País/Região como assunto: Africa Idioma: En Revista: Viruses Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Mali