Brain metastases-derived extracellular vesicles induce binding and aggregation of low-density lipoprotein.
J Nanobiotechnology
; 18(1): 162, 2020 Nov 07.
Article
em En
| MEDLINE
| ID: mdl-33160390
ABSTRACT
BACKGROUND:
Cancer cell-derived extracellular vesicles (EVs) have previously been shown to contribute to pre-metastatic niche formation. Specifically, aggressive tumors secrete pro-metastatic EVs that travel in the circulation to distant organs to modulate the microenvironment for future metastatic spread. Previous studies have focused on the interface between pro-metastatic EVs and epithelial/endothelial cells in the pre-metastatic niche. However, EV interactions with circulating components such as low-density lipoprotein (LDL) have been overlooked.RESULTS:
This study demonstrates that EVs derived from brain metastases cells (Br-EVs) and corresponding regular cancer cells (Reg-EVs) display different interactions with LDL. Specifically, Br-EVs trigger LDL aggregation, and the presence of LDL accelerates Br-EV uptake by monocytes, which are key components in the brain metastatic niche.CONCLUSIONS:
Collectively, these data are the first to demonstrate that pro-metastatic EVs display distinct interactions with LDL, which impacts monocyte internalization of EVs.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Encefálicas
/
Vesículas Extracelulares
/
Lipoproteínas LDL
Limite:
Humans
Idioma:
En
Revista:
J Nanobiotechnology
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Estados Unidos