Psychiatric Disorders in Alzheimer Disease With the Presenilin-1 L226F Mutation.
Cogn Behav Neurol
; 33(4): 278-282, 2020 12.
Article
em En
| MEDLINE
| ID: mdl-33264156
ABSTRACT
The presenilin-1 (PSEN1) L226F mutation has been linked to very early onset of prominent behavioral and psychiatric disturbances followed by cognitive decline within a few years. We report a novel case of early-onset Alzheimer disease that was originally diagnosed as psychotic depression in a patient with this gene mutation. We also compare our patient's clinical data to those of other cases of this mutation that have been described in the literature. Because atypical behavioral and psychiatric disturbances in young (<40 years) individuals can herald Alzheimer disease, a tight collaboration between psychiatrists and neurologists is crucial for an early diagnosis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Presenilina-1
/
Doença de Alzheimer
/
Transtornos Mentais
Tipo de estudo:
Diagnostic_studies
/
Screening_studies
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Cogn Behav Neurol
Assunto da revista:
NEUROLOGIA
/
PSICOLOGIA
/
PSIQUIATRIA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Itália