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Persistent or Transient Human ß Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes.
Marselli, Lorella; Piron, Anthony; Suleiman, Mara; Colli, Maikel L; Yi, Xiaoyan; Khamis, Amna; Carrat, Gaelle R; Rutter, Guy A; Bugliani, Marco; Giusti, Laura; Ronci, Maurizio; Ibberson, Mark; Turatsinze, Jean-Valery; Boggi, Ugo; De Simone, Paolo; De Tata, Vincenzo; Lopes, Miguel; Nasteska, Daniela; De Luca, Carmela; Tesi, Marta; Bosi, Emanuele; Singh, Pratibha; Campani, Daniela; Schulte, Anke M; Solimena, Michele; Hecht, Peter; Rady, Brian; Bakaj, Ivona; Pocai, Alessandro; Norquay, Lisa; Thorens, Bernard; Canouil, Mickaël; Froguel, Philippe; Eizirik, Decio L; Cnop, Miriam; Marchetti, Piero.
Afiliação
  • Marselli L; Department of Clinical and Experimental Medicine, and AOUP Cisanello University Hospital, University of Pisa, Pisa 56126, Italy. Electronic address: lorella.marselli@med.unipi.it.
  • Piron A; ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels 1070, Belgium.
  • Suleiman M; Department of Clinical and Experimental Medicine, and AOUP Cisanello University Hospital, University of Pisa, Pisa 56126, Italy.
  • Colli ML; ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels 1070, Belgium.
  • Yi X; ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels 1070, Belgium.
  • Khamis A; INSERM UMR 1283, CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille University Hospital, Lille 59000, France.
  • Carrat GR; Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology, and Metabolism, Imperial College, London, UK.
  • Rutter GA; Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology, and Metabolism, Imperial College, London, UK; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
  • Bugliani M; Department of Clinical and Experimental Medicine, and AOUP Cisanello University Hospital, University of Pisa, Pisa 56126, Italy.
  • Giusti L; Department of Clinical and Experimental Medicine, and AOUP Cisanello University Hospital, University of Pisa, Pisa 56126, Italy; School of Pharmacy, University of Camerino, Camerino, Italy.
  • Ronci M; Department of Pharmacy, University "G. d'Annunzio" of Chieti-Pescara, Chieti, Italy; Centre for Advanced Studies and Technologies (CAST), University "G. d'Annunzio" of Chieti-Pescara, Chieti, Italy.
  • Ibberson M; Vital-IT Group, Swiss Institute of Bioinformatics, Lausanne 1015, Switzerland.
  • Turatsinze JV; ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels 1070, Belgium.
  • Boggi U; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa 56126, Italy; Division of General and Transplant Surgery, Cisanello University Hospital, Pisa 56124, Italy.
  • De Simone P; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa 56126, Italy; Division of Liver Surgery and Transplantation, Cisanello University Hospital, Pisa 56124, Italy.
  • De Tata V; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa 56126, Italy.
  • Lopes M; ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels 1070, Belgium.
  • Nasteska D; ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels 1070, Belgium.
  • De Luca C; Department of Clinical and Experimental Medicine, and AOUP Cisanello University Hospital, University of Pisa, Pisa 56126, Italy.
  • Tesi M; Department of Clinical and Experimental Medicine, and AOUP Cisanello University Hospital, University of Pisa, Pisa 56126, Italy.
  • Bosi E; Department of Clinical and Experimental Medicine, and AOUP Cisanello University Hospital, University of Pisa, Pisa 56126, Italy.
  • Singh P; ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels 1070, Belgium.
  • Campani D; Department of Surgical, Medical and Molecular Pathology and the Critical Areas, University of Pisa, Pisa 56126, Italy.
  • Schulte AM; Sanofi-Aventis Deutschland GmbH, Diabetes Research, Frankfurt, Germany.
  • Solimena M; Paul Langerhans Institute Dresden of the Helmholtz Center Munich at University Hospital Carl Gustav Carus and Faculty of Medicine, TU Dresden, Dresden 01307, Germany; German Center for Diabetes Research (DZD e.V.), Neuherberg 85764, Germany.
  • Hecht P; Sanofi-Aventis Deutschland GmbH, Diabetes Research, Frankfurt, Germany.
  • Rady B; Janssen RDUS, Philadelphia, PA, USA.
  • Bakaj I; Janssen RDUS, Philadelphia, PA, USA.
  • Pocai A; Janssen RDUS, Philadelphia, PA, USA.
  • Norquay L; Janssen RDUS, Philadelphia, PA, USA.
  • Thorens B; Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.
  • Canouil M; INSERM UMR 1283, CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille University Hospital, Lille 59000, France.
  • Froguel P; Department of Metabolism, Digestion, and Reproduction, Imperial College London, London, UK.
  • Eizirik DL; ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels 1070, Belgium; WELBIO, Université Libre de Bruxelles, Brussels, Belgium; Indiana Biosciences Research Institute, Indianapolis, IN, USA; Division of Endocrinology, ULB Erasmus Hospital, Université Libre de Bruxelles, Brussels,
  • Cnop M; ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels 1070, Belgium; Division of Endocrinology, ULB Erasmus Hospital, Université Libre de Bruxelles, Brussels, Belgium. Electronic address: mcnop@ulb.ac.be.
  • Marchetti P; Department of Clinical and Experimental Medicine, and AOUP Cisanello University Hospital, University of Pisa, Pisa 56126, Italy. Electronic address: piero.marchetti@med.unipi.it.
Cell Rep ; 33(9): 108466, 2020 12 01.
Article em En | MEDLINE | ID: mdl-33264613
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estresse Fisiológico / Expressão Gênica / Diabetes Mellitus Tipo 2 / Células Secretoras de Insulina Limite: Humans Idioma: En Revista: Cell Rep Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estresse Fisiológico / Expressão Gênica / Diabetes Mellitus Tipo 2 / Células Secretoras de Insulina Limite: Humans Idioma: En Revista: Cell Rep Ano de publicação: 2020 Tipo de documento: Article