Chemoenzymatic Semi-synthesis Enables Efficient Production of Isotopically Labeled &#945;-Synuclein with Site-Specific Tyrosine Phosphorylation.

Pan, Buyan; Park, Joo Hyung; Ramlall, Trudy; Eliezer, David; Rhoades, Elizabeth; Petersson, E James

Chemoenzymatic Semi-synthesis Enables Efficient Production of Isotopically Labeled α-Synuclein with Site-Specific Tyrosine Phosphorylation.

Pan, Buyan; Park, Joo Hyung; Ramlall, Trudy; Eliezer, David; Rhoades, Elizabeth; Petersson, E James.

Afiliação

Pan B; Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, PA 19104-6323, USA.
Park JH; Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, PA 19104-6323, USA.
Ramlall T; Department of Biochemistry, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA.
Eliezer D; Department of Biochemistry, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA.
Rhoades E; Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, PA 19104-6323, USA.
Petersson EJ; Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, PA 19104-6323, USA.

Chembiochem ; 22(8): 1440-1447, 2021 04 16.

Article em En | MEDLINE | ID: mdl-33274519

Assuntos

Tirosina/metabolismo; alfa-Sinucleína/biossíntese; Estrutura Molecular; Isótopos de Nitrogênio; Ressonância Magnética Nuclear Biomolecular; Fosforilação; Tirosina/química; alfa-Sinucleína/química

Palavras-chave

NMR spectroscopy; alpha-synuclein; native chemical ligation; phosphorylation; semi-synthesis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tirosina / Alfa-Sinucleína Idioma: En Revista: Chembiochem Assunto da revista: BIOQUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

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