Neurodevelopmental Outcomes after Premedication with Atropine/Propofol vs Atropine/Atracurium/Sufentanil for Neonatal Intubation: 2-Year Follow-Up of a Randomized Clinical Trial.

Tauzin, Manon; Marchand-Martin, Laetitia; Lebeaux, Cécile; Breinig, Sophie; Claris, Olivier; Tourneux, Pierre; Alexandre, Cénéric; Levy, Corinne; Jung, Camille; Dechartres, Agnès; Durrmeyer, Xavier

Tauzin, Manon; Marchand-Martin, Laetitia; Lebeaux, Cécile; Breinig, Sophie; Claris, Olivier; Tourneux, Pierre; Alexandre, Cénéric; Levy, Corinne; Jung, Camille; Dechartres, Agnès; Durrmeyer, Xavier.

Afiliação

Tauzin M; Neonatal Intensive Care Unit, CHI Créteil, Créteil, France. Electronic address: manon.tauzin@chicreteil.fr.
Marchand-Martin L; Université de Paris, CRESS, INSERM, INRA, Paris, France.
Lebeaux C; Réseau Périnatal du Val de Marne, CHI Créteil, Créteil, France.
Breinig S; Pediatric and Neonatal Intensive Care Unit, CHU Toulouse, Toulouse, France.
Claris O; Neonatal Intensive Care Unit, Hospices Civils de Lyon, Lyon, France.
Tourneux P; Neonatal Intensive Care Unit, CHU Amiens, Amiens, France.
Alexandre C; Neonatal Intensive Care Unit, CHU Caen, Caen, France.
Levy C; ACTIV, Créteil, France; IMRB- GRC GEMINI, Université Paris Est, Créteil, France; Clinical Research Center, CHI Créteil, Créteil, France.
Jung C; Clinical Research Center, CHI Créteil, Créteil, France.
Dechartres A; Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, AP-HP. Sorbonne Université, Hôpital Pitié Salpêtrière, Département de Santé Publique, Paris, France.
Durrmeyer X; Neonatal Intensive Care Unit, CHI Créteil, Créteil, France; Université de Paris, CRESS, INSERM, INRA, Paris, France; Université Paris Est Créteil, Faculté de Médecine de Créteil, IMRB, GRC CARMAS, Créteil, France.

J Pediatr ; 231: 273-277.e3, 2021 04.

Article em En | MEDLINE | ID: mdl-33301785

ABSTRACT

ABSTRACT

This study followed 173 newborn infants in the PREmedication Trial for Tracheal Intubation of the NEOnate multicenter, double-blind, randomized controlled trial of atropine-propofol vs atropine-atracurium-sufentanil for premedication before nonemergency intubation. At 2 years of corrected age, there was no significant difference between the groups in death or risk of neurodevelopmental delay assessed with the Ages and Stages Questionnaire. Trial registration Clinicaltrials.gov NCT01490580.

Assuntos

Adjuvantes Anestésicos/administração & dosagem; Anestésicos Combinados/administração & dosagem; Atracúrio/administração & dosagem; Atropina/administração & dosagem; Intubação Intratraqueal; Sistema Nervoso/crescimento & desenvolvimento; Propofol/administração & dosagem; Sufentanil/administração & dosagem; Pré-Escolar; Método Duplo-Cego; Feminino; Seguimentos; Humanos; Recém-Nascido; Masculino; Fatores de Tempo; Resultado do Tratamento

Palavras-chave

ages and stages questionnaire; anesthesia; neurodevelopment; neurotoxicity; newborn; pain

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Atropina / Atracúrio / Propofol / Sufentanil / Anestésicos Combinados / Intubação Intratraqueal / Adjuvantes Anestésicos / Sistema Nervoso Tipo de estudo: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Child, preschool / Female / Humans / Male / Newborn Idioma: En Revista: J Pediatr Ano de publicação: 2021 Tipo de documento: Article

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