NIMA-related kinase 7 amplifies NLRP3 inflammasome pro-inflammatory signaling in microglia/macrophages and mice models of spinal cord injury.

Ji, Xubiao; Song, Zhiwen; He, Junsheng; Guo, Shiwu; Chen, Yuwei; Wang, Honghai; Zhang, Jinlong; Xu, Xu; Liu, Jinbo

Ji, Xubiao; Song, Zhiwen; He, Junsheng; Guo, Shiwu; Chen, Yuwei; Wang, Honghai; Zhang, Jinlong; Xu, Xu; Liu, Jinbo.

Afiliação

Ji X; Department of Spinal Surgery, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China; Department of Orthopedics, The Affiliated Wujin Hospital of Jiangsu University, Changzhou, 213003, China.
Song Z; Department of Spinal Surgery, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China.
He J; Department of Spinal Surgery, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China.
Guo S; Department of Spinal Surgery, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China.
Chen Y; Department of Spinal Surgery, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China.
Wang H; Department of Spinal Surgery, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China.
Zhang J; Department of Spinal Surgery, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China.
Xu X; Department of Spinal Surgery, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China.
Liu J; Department of Spinal Surgery, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China. Electronic address: czljbljb@126.com.

Exp Cell Res ; 398(2): 112418, 2021 01 15.

Article em En | MEDLINE | ID: mdl-33309808

Assuntos

Inflamassomos/metabolismo; Macrófagos/metabolismo; Microglia/metabolismo; Quinases Relacionadas a NIMA/metabolismo; Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo; Traumatismos da Medula Espinal/metabolismo; Trifosfato de Adenosina/farmacologia; Animais; Células Cultivadas; Modelos Animais de Doenças; Feminino; Lipopolissacarídeos/farmacologia; Macrófagos/efeitos dos fármacos; Camundongos; Camundongos Endogâmicos C57BL; Microglia/efeitos dos fármacos; RNA Mensageiro/metabolismo; Transdução de Sinais/efeitos dos fármacos; Traumatismos da Medula Espinal/cirurgia

Palavras-chave

Inflammasome; Microglia/Macrophage; NEK7; NLRP3; Spinal cord injury

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Traumatismos da Medula Espinal / Microglia / Inflamassomos / Quinases Relacionadas a NIMA / Proteína 3 que Contém Domínio de Pirina da Família NLR / Macrófagos Limite: Animals Idioma: En Revista: Exp Cell Res Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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